Design of prospective clinical trials for assessment of PET

James Fletcher, Elizabeth Adams, Karen Flynn, Frank J. Papatheofanis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This article will briefly review measures of accuracy for diagnostic tests. We will present valid, methodologically rigorous prospective clinical trial design features that avoid bias and that can generate high-quality evidence on the diagnostic accuracy of PET and its impact on diagnostic decision-making and therapeutic efficacy. Knowledge of the principles of Evidence-based Medicine, and an understanding of the key elements of designing a methodologically rigorous, prospective clinical trial will permit avoidance of the previous study design limitations and weaknesses of the existing literature on diagnostic imaging modalities. Published results of studies that are valid, obtained rapidly, and generalizable, will provide important support for the paradigm shift away from informal, opinion-driven decision-making in health care, toward a process that is evidence-based, rationale and considerate of our available resources and their most effective use in patient care.

Original languageEnglish (US)
Pages (from-to)201-211
Number of pages11
JournalClinical Positron Imaging (Netherlands)
Volume1
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Decision Making
Clinical Trials
Evidence-Based Medicine
Diagnostic Imaging
Routine Diagnostic Tests
Patient Care
Delivery of Health Care
Therapeutics

Keywords

  • Clinical trials
  • Efficacy
  • Evidence-based medicine
  • Positron emission tomography
  • Study design

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Design of prospective clinical trials for assessment of PET. / Fletcher, James; Adams, Elizabeth; Flynn, Karen; Papatheofanis, Frank J.

In: Clinical Positron Imaging (Netherlands), Vol. 1, No. 3, 1998, p. 201-211.

Research output: Contribution to journalArticle

Fletcher, James ; Adams, Elizabeth ; Flynn, Karen ; Papatheofanis, Frank J. / Design of prospective clinical trials for assessment of PET. In: Clinical Positron Imaging (Netherlands). 1998 ; Vol. 1, No. 3. pp. 201-211.
@article{7f57808d93a24e65a30a360aa47ea7c5,
title = "Design of prospective clinical trials for assessment of PET",
abstract = "This article will briefly review measures of accuracy for diagnostic tests. We will present valid, methodologically rigorous prospective clinical trial design features that avoid bias and that can generate high-quality evidence on the diagnostic accuracy of PET and its impact on diagnostic decision-making and therapeutic efficacy. Knowledge of the principles of Evidence-based Medicine, and an understanding of the key elements of designing a methodologically rigorous, prospective clinical trial will permit avoidance of the previous study design limitations and weaknesses of the existing literature on diagnostic imaging modalities. Published results of studies that are valid, obtained rapidly, and generalizable, will provide important support for the paradigm shift away from informal, opinion-driven decision-making in health care, toward a process that is evidence-based, rationale and considerate of our available resources and their most effective use in patient care.",
keywords = "Clinical trials, Efficacy, Evidence-based medicine, Positron emission tomography, Study design",
author = "James Fletcher and Elizabeth Adams and Karen Flynn and Papatheofanis, {Frank J.}",
year = "1998",
doi = "10.1016/S1095-0397(98)00016-8",
language = "English (US)",
volume = "1",
pages = "201--211",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Design of prospective clinical trials for assessment of PET

AU - Fletcher, James

AU - Adams, Elizabeth

AU - Flynn, Karen

AU - Papatheofanis, Frank J.

PY - 1998

Y1 - 1998

N2 - This article will briefly review measures of accuracy for diagnostic tests. We will present valid, methodologically rigorous prospective clinical trial design features that avoid bias and that can generate high-quality evidence on the diagnostic accuracy of PET and its impact on diagnostic decision-making and therapeutic efficacy. Knowledge of the principles of Evidence-based Medicine, and an understanding of the key elements of designing a methodologically rigorous, prospective clinical trial will permit avoidance of the previous study design limitations and weaknesses of the existing literature on diagnostic imaging modalities. Published results of studies that are valid, obtained rapidly, and generalizable, will provide important support for the paradigm shift away from informal, opinion-driven decision-making in health care, toward a process that is evidence-based, rationale and considerate of our available resources and their most effective use in patient care.

AB - This article will briefly review measures of accuracy for diagnostic tests. We will present valid, methodologically rigorous prospective clinical trial design features that avoid bias and that can generate high-quality evidence on the diagnostic accuracy of PET and its impact on diagnostic decision-making and therapeutic efficacy. Knowledge of the principles of Evidence-based Medicine, and an understanding of the key elements of designing a methodologically rigorous, prospective clinical trial will permit avoidance of the previous study design limitations and weaknesses of the existing literature on diagnostic imaging modalities. Published results of studies that are valid, obtained rapidly, and generalizable, will provide important support for the paradigm shift away from informal, opinion-driven decision-making in health care, toward a process that is evidence-based, rationale and considerate of our available resources and their most effective use in patient care.

KW - Clinical trials

KW - Efficacy

KW - Evidence-based medicine

KW - Positron emission tomography

KW - Study design

UR - http://www.scopus.com/inward/record.url?scp=0006580040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0006580040&partnerID=8YFLogxK

U2 - 10.1016/S1095-0397(98)00016-8

DO - 10.1016/S1095-0397(98)00016-8

M3 - Article

VL - 1

SP - 201

EP - 211

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 3

ER -