Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, Zhong Yin Zhang, Xin Zhou, Zhong Xing Jiang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

Original languageEnglish (US)
Pages (from-to)1672-1680
Number of pages9
JournalMedChemComm
Volume7
Issue number8
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Li, Y., Xia, G., Guo, Q., Wu, L., Chen, S., Yang, Z., Wang, W., Zhang, Z. Y., Zhou, X., & Jiang, Z. X. (2016). Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. MedChemComm, 7(8), 1672-1680. https://doi.org/10.1039/c6md00277c