Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, Zhong-Yin Zhang, Xin Zhou, Zhong Xing Jiang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

Original languageEnglish (US)
Pages (from-to)1672-1680
Number of pages9
JournalMedChemComm
Volume7
Issue number8
DOIs
StatePublished - 2016
Externally publishedYes

Fingerprint

Protein Tyrosine Phosphatases
Magnetic resonance
Magnetic Resonance Spectroscopy
Fluorine
Imaging techniques
Pharmaceutical Chemistry
Drug Discovery
Libraries
Technology
Research

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. / Li, Yu; Xia, Guiquan; Guo, Qi; Wu, Li; Chen, Shizhen; Yang, Zhigang; Wang, Wei; Zhang, Zhong-Yin; Zhou, Xin; Jiang, Zhong Xing.

In: MedChemComm, Vol. 7, No. 8, 2016, p. 1672-1680.

Research output: Contribution to journalArticle

Li, Y, Xia, G, Guo, Q, Wu, L, Chen, S, Yang, Z, Wang, W, Zhang, Z-Y, Zhou, X & Jiang, ZX 2016, 'Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors', MedChemComm, vol. 7, no. 8, pp. 1672-1680. https://doi.org/10.1039/c6md00277c
Li, Yu ; Xia, Guiquan ; Guo, Qi ; Wu, Li ; Chen, Shizhen ; Yang, Zhigang ; Wang, Wei ; Zhang, Zhong-Yin ; Zhou, Xin ; Jiang, Zhong Xing. / Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors. In: MedChemComm. 2016 ; Vol. 7, No. 8. pp. 1672-1680.
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