Designs for clinical trials to test the efficacy of therapeutics in progressive multifocal leukoencephalopathy

C. T. Yiannoutsos, A. De Luca

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The design of a comparative treatment trial to evaluate the efficacy of therapeutics for progressive multifocal leukoencephalopathy (PML) is outlined. We propose a large simple randomized trial with patient survival as its primary endpoint, completed in a short period of time and involving a cohort with as few enrollment restrictions as possible. We use stratification as the counter-weight to the lack of exclusion criteria and suggest that proper stratification will attenuate differences inherent in a heterogeneous subject cohort. Estimation of power, sample size, and study duration, implementation of interim analyses, toxicity management, and validation of secondary clinical measures are also addressed.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalJournal of NeuroVirology
Volume7
Issue number4
DOIs
StatePublished - Oct 4 2001
Externally publishedYes

Keywords

  • Clinical protocol
  • HIV
  • Patient selection
  • Sample size

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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