Destruction of canals of Hering in primary biliary cirrhosis

Romil Saxena, Prodromos Hytiroglou, Swan N. Thung, Neil D. Theise

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The canals of Hering (CoH), converging from the hepatic lobule onto the portal tract, connect bile canaliculi to the interlobular bile ducts, and represent the most proximal portion of the bile drainage pathway with a cholangiocyte lining. In this study we sought to ascertain whether this proximal pathway is involved by the disease process in primary biliary cirrhosis (PBC), which uniformly affects small bile ducts while sparing medium- and large-sized ducts. Ten biopsy specimens with early-stage PBC were compared with 6 normal control livers. Adjacent 4-μ-thick sections of routinely processed, formalin-fixed tissue were immunostained for CK19 and HLA-DR. Each terminal portal tract was assigned a stage: 0, normal; 1, bile duct damage or loss; 2, bile ductular proliferation; or 3, periportal fibrosis. The ratio of the number of CoH to number of portal tracts (i.e., the c/p ratio) was calculated for the control biopsies and individual portal tracts at each stage of PBC. The numbers of CoH were decreased in all stages of PBC (P

Original languageEnglish (US)
Pages (from-to)983-988
Number of pages6
JournalHuman Pathology
Volume33
Issue number10
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

Fingerprint

Biliary Liver Cirrhosis
Bile Ducts
Bile
Bile Canaliculi
Biopsy
Liver
HLA-DR Antigens
Formaldehyde
Drainage
Fibrosis

Keywords

  • Autoimmune
  • Bile ducts
  • Cholangiopathy
  • Ductular proliferation
  • Stem cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Destruction of canals of Hering in primary biliary cirrhosis. / Saxena, Romil; Hytiroglou, Prodromos; Thung, Swan N.; Theise, Neil D.

In: Human Pathology, Vol. 33, No. 10, 01.10.2002, p. 983-988.

Research output: Contribution to journalArticle

Saxena, Romil ; Hytiroglou, Prodromos ; Thung, Swan N. ; Theise, Neil D. / Destruction of canals of Hering in primary biliary cirrhosis. In: Human Pathology. 2002 ; Vol. 33, No. 10. pp. 983-988.
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