Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes

Christopher R. Cogle, Elizabeth Wise, Amy M. Meacham, Claudia Zierold, Jay H. Traverse, Timothy D. Henry, Emerson C. Perin, James T. Willerson, Stephen G. Ellis, Marjorie Carlson, David X M Zhao, Roberto Bolli, John P. Cooke, Saif Anwaruddin, Aruni Bhatnagar, Maria Da Graca Cabreira-Hansen, Maria B. Grant, Dejian Lai, Lem Moyé, Ray F. Ebert & 8 others Rachel E. Olson, Shelly L. Sayre, Ivonne H. Schulman, Raphael C. Bosse, Edward W. Scott, Robert D. Simari, Carl J. Pepine, Doris A. Taylor

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Rationale: Bone marrow (BM) cell therapy for ischemic heart disease (IHD) has shown mixed results. Before the full potency of BM cell therapy can be realized, it is essential to understand the BM niche after acute myocardial infarction (AMI). Objective: To study the BM composition in patients with IHD and severe left ventricular (LV) dysfunction. Methods and Results: BM from 280 patients with IHD and LV dysfunction were analyzed for cell subsets by flow cytometry and colony assays. BM CD34+ cell percentage was decreased 7 days after AMI (mean of 1.9% versus 2.3%-2.7% in other cohorts; P

Original languageEnglish (US)
Pages (from-to)867-874
Number of pages8
JournalCirculation Research
Volume115
Issue number10
DOIs
StatePublished - 2014
Externally publishedYes

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Left Ventricular Dysfunction
Bone Marrow Cells
Myocardial Ischemia
Biomarkers
Bone Marrow
Cell- and Tissue-Based Therapy
Myocardial Infarction
Flow Cytometry

Keywords

  • Angiogenesis effect
  • Blood cells
  • Bone marrow
  • Myocardial infarction
  • Stem cells

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes. / Cogle, Christopher R.; Wise, Elizabeth; Meacham, Amy M.; Zierold, Claudia; Traverse, Jay H.; Henry, Timothy D.; Perin, Emerson C.; Willerson, James T.; Ellis, Stephen G.; Carlson, Marjorie; Zhao, David X M; Bolli, Roberto; Cooke, John P.; Anwaruddin, Saif; Bhatnagar, Aruni; Da Graca Cabreira-Hansen, Maria; Grant, Maria B.; Lai, Dejian; Moyé, Lem; Ebert, Ray F.; Olson, Rachel E.; Sayre, Shelly L.; Schulman, Ivonne H.; Bosse, Raphael C.; Scott, Edward W.; Simari, Robert D.; Pepine, Carl J.; Taylor, Doris A.

In: Circulation Research, Vol. 115, No. 10, 2014, p. 867-874.

Research output: Contribution to journalArticle

Cogle, CR, Wise, E, Meacham, AM, Zierold, C, Traverse, JH, Henry, TD, Perin, EC, Willerson, JT, Ellis, SG, Carlson, M, Zhao, DXM, Bolli, R, Cooke, JP, Anwaruddin, S, Bhatnagar, A, Da Graca Cabreira-Hansen, M, Grant, MB, Lai, D, Moyé, L, Ebert, RF, Olson, RE, Sayre, SL, Schulman, IH, Bosse, RC, Scott, EW, Simari, RD, Pepine, CJ & Taylor, DA 2014, 'Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes', Circulation Research, vol. 115, no. 10, pp. 867-874. https://doi.org/10.1161/CIRCRESAHA.115.304353
Cogle, Christopher R. ; Wise, Elizabeth ; Meacham, Amy M. ; Zierold, Claudia ; Traverse, Jay H. ; Henry, Timothy D. ; Perin, Emerson C. ; Willerson, James T. ; Ellis, Stephen G. ; Carlson, Marjorie ; Zhao, David X M ; Bolli, Roberto ; Cooke, John P. ; Anwaruddin, Saif ; Bhatnagar, Aruni ; Da Graca Cabreira-Hansen, Maria ; Grant, Maria B. ; Lai, Dejian ; Moyé, Lem ; Ebert, Ray F. ; Olson, Rachel E. ; Sayre, Shelly L. ; Schulman, Ivonne H. ; Bosse, Raphael C. ; Scott, Edward W. ; Simari, Robert D. ; Pepine, Carl J. ; Taylor, Doris A. / Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes. In: Circulation Research. 2014 ; Vol. 115, No. 10. pp. 867-874.
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AU - Meacham, Amy M.

AU - Zierold, Claudia

AU - Traverse, Jay H.

AU - Henry, Timothy D.

AU - Perin, Emerson C.

AU - Willerson, James T.

AU - Ellis, Stephen G.

AU - Carlson, Marjorie

AU - Zhao, David X M

AU - Bolli, Roberto

AU - Cooke, John P.

AU - Anwaruddin, Saif

AU - Bhatnagar, Aruni

AU - Da Graca Cabreira-Hansen, Maria

AU - Grant, Maria B.

AU - Lai, Dejian

AU - Moyé, Lem

AU - Ebert, Ray F.

AU - Olson, Rachel E.

AU - Sayre, Shelly L.

AU - Schulman, Ivonne H.

AU - Bosse, Raphael C.

AU - Scott, Edward W.

AU - Simari, Robert D.

AU - Pepine, Carl J.

AU - Taylor, Doris A.

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