Detection and treatment of post kidney transplant hyperglycemia: A spanish multicenter cross-sectional study

A. Martínez-Castelao, M. D. Hernández, J. Pascual, J. M. Morales, R. Marcen, P. Errasti, R. Romero, J. Oliver, L. Jimeno, J. Garcia Martinez, A. Mendiluce, P. Garcia Cosme, A. Mazuecos, D. Danz-Guajardo, A. Alarcon, David Marrero

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Abstract

Introduction. The prevalence of diabetes mellitus (DM) is greater among patients with solid organ transplants than in the general population, although the factors associated with posttransplant DM (PTDM) are unknown. Objectives. The objective of this study was to estimate the prevalence of and assess the risk factors for PTDM. Patients and Methods. We included outpatients with functioning isolated solid organ allografts (kidney, liver, heart, and lung). We collected demographic and posttransplant clinical data that included DM diagnostic ADA criteria, DM treatment, DM family history, presence of hepatitis C virus (HCV), immunosuppression treatment, hypertension, and dyslipidemia. Results. A total of 2178 patients included, 1410 kidney recipients, 489 liver transplants, 207 heart transplants, and 72 lung recipients. Seventeen and four-tenths percent of the patients who did not have DM prior to transplantation, developed PTDM (median time: 79 days). A greater prevalence was observed among patients with a family history, HCV, and tacrolimus treatment (with or without steroids P <.05). By logistic regression analyses, OR for these factors were 1.51, 1.65, and 1.38, respectively. Of those patients who did not suffer PTDM, 55.2% showed basal blood glucose values under 100 mg/dL; only 68% presented with a hemoglobin Alc under 6. Conclusions. The prevalence of PTDM among kidney recipients was higher than that in the general population. DM family history, HCV positive, and tacrolimus were risk factors associated with this entity.

Original languageEnglish (US)
Pages (from-to)3813-3816
Number of pages4
JournalTransplantation Proceedings
Volume37
Issue number9
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Hyperglycemia
Diabetes Mellitus
Cross-Sectional Studies
Transplants
Kidney
Hepacivirus
Tacrolimus
Therapeutics
Lung
Liver
Dyslipidemias
Immunosuppression
Population
Allografts
Blood Glucose
Hemoglobins
Outpatients
Transplantation
Logistic Models
Steroids

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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Detection and treatment of post kidney transplant hyperglycemia : A spanish multicenter cross-sectional study. / Martínez-Castelao, A.; Hernández, M. D.; Pascual, J.; Morales, J. M.; Marcen, R.; Errasti, P.; Romero, R.; Oliver, J.; Jimeno, L.; Garcia Martinez, J.; Mendiluce, A.; Garcia Cosme, P.; Mazuecos, A.; Danz-Guajardo, D.; Alarcon, A.; Marrero, David.

In: Transplantation Proceedings, Vol. 37, No. 9, 11.2005, p. 3813-3816.

Research output: Contribution to journalArticle

Martínez-Castelao, A, Hernández, MD, Pascual, J, Morales, JM, Marcen, R, Errasti, P, Romero, R, Oliver, J, Jimeno, L, Garcia Martinez, J, Mendiluce, A, Garcia Cosme, P, Mazuecos, A, Danz-Guajardo, D, Alarcon, A & Marrero, D 2005, 'Detection and treatment of post kidney transplant hyperglycemia: A spanish multicenter cross-sectional study', Transplantation Proceedings, vol. 37, no. 9, pp. 3813-3816. https://doi.org/10.1016/j.transproceed.2005.10.035
Martínez-Castelao, A. ; Hernández, M. D. ; Pascual, J. ; Morales, J. M. ; Marcen, R. ; Errasti, P. ; Romero, R. ; Oliver, J. ; Jimeno, L. ; Garcia Martinez, J. ; Mendiluce, A. ; Garcia Cosme, P. ; Mazuecos, A. ; Danz-Guajardo, D. ; Alarcon, A. ; Marrero, David. / Detection and treatment of post kidney transplant hyperglycemia : A spanish multicenter cross-sectional study. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 9. pp. 3813-3816.
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abstract = "Introduction. The prevalence of diabetes mellitus (DM) is greater among patients with solid organ transplants than in the general population, although the factors associated with posttransplant DM (PTDM) are unknown. Objectives. The objective of this study was to estimate the prevalence of and assess the risk factors for PTDM. Patients and Methods. We included outpatients with functioning isolated solid organ allografts (kidney, liver, heart, and lung). We collected demographic and posttransplant clinical data that included DM diagnostic ADA criteria, DM treatment, DM family history, presence of hepatitis C virus (HCV), immunosuppression treatment, hypertension, and dyslipidemia. Results. A total of 2178 patients included, 1410 kidney recipients, 489 liver transplants, 207 heart transplants, and 72 lung recipients. Seventeen and four-tenths percent of the patients who did not have DM prior to transplantation, developed PTDM (median time: 79 days). A greater prevalence was observed among patients with a family history, HCV, and tacrolimus treatment (with or without steroids P <.05). By logistic regression analyses, OR for these factors were 1.51, 1.65, and 1.38, respectively. Of those patients who did not suffer PTDM, 55.2{\%} showed basal blood glucose values under 100 mg/dL; only 68{\%} presented with a hemoglobin Alc under 6. Conclusions. The prevalence of PTDM among kidney recipients was higher than that in the general population. DM family history, HCV positive, and tacrolimus were risk factors associated with this entity.",
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T1 - Detection and treatment of post kidney transplant hyperglycemia

T2 - A spanish multicenter cross-sectional study

AU - Martínez-Castelao, A.

AU - Hernández, M. D.

AU - Pascual, J.

AU - Morales, J. M.

AU - Marcen, R.

AU - Errasti, P.

AU - Romero, R.

AU - Oliver, J.

AU - Jimeno, L.

AU - Garcia Martinez, J.

AU - Mendiluce, A.

AU - Garcia Cosme, P.

AU - Mazuecos, A.

AU - Danz-Guajardo, D.

AU - Alarcon, A.

AU - Marrero, David

PY - 2005/11

Y1 - 2005/11

N2 - Introduction. The prevalence of diabetes mellitus (DM) is greater among patients with solid organ transplants than in the general population, although the factors associated with posttransplant DM (PTDM) are unknown. Objectives. The objective of this study was to estimate the prevalence of and assess the risk factors for PTDM. Patients and Methods. We included outpatients with functioning isolated solid organ allografts (kidney, liver, heart, and lung). We collected demographic and posttransplant clinical data that included DM diagnostic ADA criteria, DM treatment, DM family history, presence of hepatitis C virus (HCV), immunosuppression treatment, hypertension, and dyslipidemia. Results. A total of 2178 patients included, 1410 kidney recipients, 489 liver transplants, 207 heart transplants, and 72 lung recipients. Seventeen and four-tenths percent of the patients who did not have DM prior to transplantation, developed PTDM (median time: 79 days). A greater prevalence was observed among patients with a family history, HCV, and tacrolimus treatment (with or without steroids P <.05). By logistic regression analyses, OR for these factors were 1.51, 1.65, and 1.38, respectively. Of those patients who did not suffer PTDM, 55.2% showed basal blood glucose values under 100 mg/dL; only 68% presented with a hemoglobin Alc under 6. Conclusions. The prevalence of PTDM among kidney recipients was higher than that in the general population. DM family history, HCV positive, and tacrolimus were risk factors associated with this entity.

AB - Introduction. The prevalence of diabetes mellitus (DM) is greater among patients with solid organ transplants than in the general population, although the factors associated with posttransplant DM (PTDM) are unknown. Objectives. The objective of this study was to estimate the prevalence of and assess the risk factors for PTDM. Patients and Methods. We included outpatients with functioning isolated solid organ allografts (kidney, liver, heart, and lung). We collected demographic and posttransplant clinical data that included DM diagnostic ADA criteria, DM treatment, DM family history, presence of hepatitis C virus (HCV), immunosuppression treatment, hypertension, and dyslipidemia. Results. A total of 2178 patients included, 1410 kidney recipients, 489 liver transplants, 207 heart transplants, and 72 lung recipients. Seventeen and four-tenths percent of the patients who did not have DM prior to transplantation, developed PTDM (median time: 79 days). A greater prevalence was observed among patients with a family history, HCV, and tacrolimus treatment (with or without steroids P <.05). By logistic regression analyses, OR for these factors were 1.51, 1.65, and 1.38, respectively. Of those patients who did not suffer PTDM, 55.2% showed basal blood glucose values under 100 mg/dL; only 68% presented with a hemoglobin Alc under 6. Conclusions. The prevalence of PTDM among kidney recipients was higher than that in the general population. DM family history, HCV positive, and tacrolimus were risk factors associated with this entity.

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