Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas

Tomislav Novosel, Hadley Ritter, Manjula Gupta, Adrian Harvey, Jamie Mitchell, Eren Berber, Allan Siperstein, Mira Milas

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Circulating thyroid cancer cells detected by peripheral blood thyroid-stimulating hormone receptor (TSHR) mRNA have demonstrated usefulness for thyroid cancer diagnosis and long-term surveillance. The aim of this study was to determine detectability and clinical importance of TSHR mRNA in patients with microcarcinomas. Methods: We compared clinical characteristics of 37 patients with papillary thyroid microcarcinomas (PTMC; tumor size ≤1 cm) having undetectable (-) versus detectable (+)TSHR mRNA. Results: 59 Of the PTMC patients, 59% had (+)TSHR mRNA levels, similar to those with tumors >1 cm (72%; P = NS) and distinctly higher than false (+) rates in benign goiters (15%; P <.001). All patients with (-)TSHR mRNA had classical PTMC, whereas variants (32%) occurred with (+)mRNA (P = .001). Mean tumor size (5 mm) and multifocality rates (45%) were similar in both mRNA groups. Of the PTMC patients, 35% had concurrent cervical nodal metastases, which occurred more frequently with tumors ≥5 mm (P = .04) and with (+)TSHR mRNA in pre-operatively known PTMC (P <.05). No patients with incidentally detected PTMC and (-)TSHR mRNA had metastases. Conclusion: This study is the first to demonstrate that TSHR mRNA, reflecting circulating thyroid cancer cells, is detectable even with thyroid microcarcinomas. PTMC with (+)TSHR mRNA may characterize patients with potentially more aggressive histology at initial operation.

Original languageEnglish (US)
Pages (from-to)1081-1089
Number of pages9
JournalSurgery
Volume146
Issue number6
DOIs
StatePublished - Dec 2009
Externally publishedYes

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Thyrotropin Receptors
Thyroid Neoplasms
Thyroid Gland
Messenger RNA
Neoplasms
Neoplasm Metastasis
Goiter
Histology

ASJC Scopus subject areas

  • Surgery

Cite this

Novosel, T., Ritter, H., Gupta, M., Harvey, A., Mitchell, J., Berber, E., ... Milas, M. (2009). Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas. Surgery, 146(6), 1081-1089. https://doi.org/10.1016/j.surg.2009.09.008

Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas. / Novosel, Tomislav; Ritter, Hadley; Gupta, Manjula; Harvey, Adrian; Mitchell, Jamie; Berber, Eren; Siperstein, Allan; Milas, Mira.

In: Surgery, Vol. 146, No. 6, 12.2009, p. 1081-1089.

Research output: Contribution to journalArticle

Novosel, T, Ritter, H, Gupta, M, Harvey, A, Mitchell, J, Berber, E, Siperstein, A & Milas, M 2009, 'Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas', Surgery, vol. 146, no. 6, pp. 1081-1089. https://doi.org/10.1016/j.surg.2009.09.008
Novosel, Tomislav ; Ritter, Hadley ; Gupta, Manjula ; Harvey, Adrian ; Mitchell, Jamie ; Berber, Eren ; Siperstein, Allan ; Milas, Mira. / Detection of circulating thyroid cancer cells in patients with thyroid microcarcinomas. In: Surgery. 2009 ; Vol. 146, No. 6. pp. 1081-1089.
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