Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation

Paul Haut, P. Kovarik, P. H. Shaw, D. Walterhouse, H. B. Jenson, M. Kletzel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.

Original languageEnglish (US)
Pages (from-to)761-765
Number of pages5
JournalBone Marrow Transplantation
Volume27
Issue number7
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Lymphoproliferative Disorders
Blood Donors
Human Herpesvirus 4
Fetal Blood
Transplantation
Transplants
DNA
Juvenile Myelomonocytic Leukemia
Epstein-Barr Virus Infections
Acyclovir
Stem Cell Transplantation
Interferon-alpha
Stem Cells
Tissue Donors
Lymphocytes
Polymerase Chain Reaction

Keywords

  • EBV
  • PTLD
  • Transplant
  • Umbilical cord blood

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation. / Haut, Paul; Kovarik, P.; Shaw, P. H.; Walterhouse, D.; Jenson, H. B.; Kletzel, M.

In: Bone Marrow Transplantation, Vol. 27, No. 7, 2001, p. 761-765.

Research output: Contribution to journalArticle

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