Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results

Lindsey Egan, Patricia A. Connolly, Deanna Fuller, Thomas E. Davis, John Witt, Kenneth S. Knox, Chadi A. Hage, L. Joseph Wheat

Research output: Contribution to journalArticle

14 Scopus citations


Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Original languageEnglish (US)
Pages (from-to)726-728
Number of pages3
JournalClinical and Vaccine Immunology
Issue number4
StatePublished - Apr 1 2008


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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