Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results

Lindsey Egan, Patricia A. Connolly, Deanna Fuller, Thomas Davis, John Witt, Kenneth S. Knox, Chadi Hage, L. Joseph Wheat

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Original languageEnglish
Pages (from-to)726-728
Number of pages3
JournalClinical and Vaccine Immunology
Volume15
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Histoplasma
Ultrafiltration
Antigens
Histoplasmosis
Limit of Detection
Assays

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results. / Egan, Lindsey; Connolly, Patricia A.; Fuller, Deanna; Davis, Thomas; Witt, John; Knox, Kenneth S.; Hage, Chadi; Wheat, L. Joseph.

In: Clinical and Vaccine Immunology, Vol. 15, No. 4, 04.2008, p. 726-728.

Research output: Contribution to journalArticle

Egan, Lindsey ; Connolly, Patricia A. ; Fuller, Deanna ; Davis, Thomas ; Witt, John ; Knox, Kenneth S. ; Hage, Chadi ; Wheat, L. Joseph. / Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results. In: Clinical and Vaccine Immunology. 2008 ; Vol. 15, No. 4. pp. 726-728.
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