Detection of links between Ebola nucleocapsid and virulence using disorder analysis

Gerard Kian Meng Goh, A. Dunker, Vladimir N. Uversky

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.

Original languageEnglish (US)
Pages (from-to)2337-2344
Number of pages8
JournalMolecular BioSystems
Volume11
Issue number8
DOIs
StatePublished - May 22 2015

Fingerprint

Ebolavirus
Nucleocapsid
Virulence
Nucleocapsid Proteins
Viral RNA
Viral Proteins
Protein Binding
Virion
Cytoplasm
Vaccines
Viruses
Membranes
Mortality
Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

Cite this

Detection of links between Ebola nucleocapsid and virulence using disorder analysis. / Goh, Gerard Kian Meng; Dunker, A.; Uversky, Vladimir N.

In: Molecular BioSystems, Vol. 11, No. 8, 22.05.2015, p. 2337-2344.

Research output: Contribution to journalArticle

Goh, Gerard Kian Meng ; Dunker, A. ; Uversky, Vladimir N. / Detection of links between Ebola nucleocapsid and virulence using disorder analysis. In: Molecular BioSystems. 2015 ; Vol. 11, No. 8. pp. 2337-2344.
@article{85000cafce4b40898e03466e1eae12b7,
title = "Detection of links between Ebola nucleocapsid and virulence using disorder analysis",
abstract = "The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.",
author = "Goh, {Gerard Kian Meng} and A. Dunker and Uversky, {Vladimir N.}",
year = "2015",
month = "5",
day = "22",
doi = "10.1039/c5mb00240k",
language = "English (US)",
volume = "11",
pages = "2337--2344",
journal = "Molecular BioSystems",
issn = "1742-206X",
publisher = "Royal Society of Chemistry",
number = "8",

}

TY - JOUR

T1 - Detection of links between Ebola nucleocapsid and virulence using disorder analysis

AU - Goh, Gerard Kian Meng

AU - Dunker, A.

AU - Uversky, Vladimir N.

PY - 2015/5/22

Y1 - 2015/5/22

N2 - The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.

AB - The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.

UR - http://www.scopus.com/inward/record.url?scp=84950322319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950322319&partnerID=8YFLogxK

U2 - 10.1039/c5mb00240k

DO - 10.1039/c5mb00240k

M3 - Article

C2 - 26086270

AN - SCOPUS:84950322319

VL - 11

SP - 2337

EP - 2344

JO - Molecular BioSystems

JF - Molecular BioSystems

SN - 1742-206X

IS - 8

ER -