Detection of links between Ebola nucleocapsid and virulence using disorder analysis

Gerard Kian Meng Goh, A. Keith Dunker, Vladimir N. Uversky

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these proteins is likely to be needed for more efficient multiplication of virus copies via more efficient viral RNA transcription and more promiscuous protein binding potential. This is important for the more efficient assistance of nucleocapsid in viral particle budding and of the assembly and mobility of viral proteins across the host membrane and within the cytoplasm. A more comprehensive knowledge of the molecular mechanisms of EBOV virulence would also lead to new and more effective strategies in vaccine development.

Original languageEnglish (US)
Pages (from-to)2337-2344
Number of pages8
JournalMolecular BioSystems
Volume11
Issue number8
DOIs
StatePublished - May 22 2015

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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