Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT

Donald L. Budenz, Douglas R. Anderson, Rohit Varma, Joel Schuman, Louis Cantor, Jonathan Savell, David S. Greenfield, Vincent Michael Patella, Harry A. Quigley, James Tielsch

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Abstract

Purpose: To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography). Design: Cross-sectional observational study. Participants: Three hundred twenty-eight normal subjects 18 to 85 years old. Methods: Peripapillary Fast RNFL scans performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc were performed on one randomly selected eye of each subject. Main Outcome Measures: Linear regression analysis of the effects of age, ethnicity, gender, eye, axial length, and optic disc area on peripapillary RNFL thickness. Results: The mean RNFL thickness for the entire population was 100.1 μm (standard deviation, 11.6). Thinner RNFL measurements were associated with older age (P<0.001); being Caucasian, versus being either Hispanic or Asian (P = 0.006); greater axial length (P<0.001); or smaller optic disc area (P = 0.010). For every decade of increased age, mean RNFL thickness measured thinner by approximately 2.0 μm (95% confidence interval [CI], 1.2-2.8). For every 1-mm-greater axial length, mean RNFL thickness measured thinner by approximately 2.2 μm (95% CI, 1.1-3.4). For every increase in square millimeter of optic disc area, mean RNFL thickness increased by approximately 3.3 μm (95% CI, 0.6-5.6). Comparisons between ethnic groups revealed that Caucasians had mean RNFL values (98.1±10.9 μm) slightly thinner than those of Hispanics (103.7±11.6 μm; P = 0.022) or Asians (105.8±9.2 μm; P = 0.043). There was no relationship between RNFL thickness and eye or gender. Conclusions: Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range. Due to the relatively small numbers of subjects of Asian and African descent in the normative database, conclusions regarding the effect of ethnicity should be interpreted with caution.

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalOphthalmology
Volume114
Issue number6
DOIs
StatePublished - Jun 2007

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Optical Coherence Tomography
Nerve Fibers
Optic Disk
Eye Axial Length
Confidence Intervals
Hispanic Americans
Ethnic Groups
Glaucoma
Observational Studies
Linear Models
Reference Values
Cross-Sectional Studies
Regression Analysis
Outcome Assessment (Health Care)
Databases

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Budenz, D. L., Anderson, D. R., Varma, R., Schuman, J., Cantor, L., Savell, J., ... Tielsch, J. (2007). Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT. Ophthalmology, 114(6), 1046-1052. https://doi.org/10.1016/j.ophtha.2006.08.046

Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT. / Budenz, Donald L.; Anderson, Douglas R.; Varma, Rohit; Schuman, Joel; Cantor, Louis; Savell, Jonathan; Greenfield, David S.; Patella, Vincent Michael; Quigley, Harry A.; Tielsch, James.

In: Ophthalmology, Vol. 114, No. 6, 06.2007, p. 1046-1052.

Research output: Contribution to journalArticle

Budenz, DL, Anderson, DR, Varma, R, Schuman, J, Cantor, L, Savell, J, Greenfield, DS, Patella, VM, Quigley, HA & Tielsch, J 2007, 'Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT', Ophthalmology, vol. 114, no. 6, pp. 1046-1052. https://doi.org/10.1016/j.ophtha.2006.08.046
Budenz, Donald L. ; Anderson, Douglas R. ; Varma, Rohit ; Schuman, Joel ; Cantor, Louis ; Savell, Jonathan ; Greenfield, David S. ; Patella, Vincent Michael ; Quigley, Harry A. ; Tielsch, James. / Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCT. In: Ophthalmology. 2007 ; Vol. 114, No. 6. pp. 1046-1052.
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AU - Anderson, Douglas R.

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AU - Cantor, Louis

AU - Savell, Jonathan

AU - Greenfield, David S.

AU - Patella, Vincent Michael

AU - Quigley, Harry A.

AU - Tielsch, James

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N2 - Purpose: To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography). Design: Cross-sectional observational study. Participants: Three hundred twenty-eight normal subjects 18 to 85 years old. Methods: Peripapillary Fast RNFL scans performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc were performed on one randomly selected eye of each subject. Main Outcome Measures: Linear regression analysis of the effects of age, ethnicity, gender, eye, axial length, and optic disc area on peripapillary RNFL thickness. Results: The mean RNFL thickness for the entire population was 100.1 μm (standard deviation, 11.6). Thinner RNFL measurements were associated with older age (P<0.001); being Caucasian, versus being either Hispanic or Asian (P = 0.006); greater axial length (P<0.001); or smaller optic disc area (P = 0.010). For every decade of increased age, mean RNFL thickness measured thinner by approximately 2.0 μm (95% confidence interval [CI], 1.2-2.8). For every 1-mm-greater axial length, mean RNFL thickness measured thinner by approximately 2.2 μm (95% CI, 1.1-3.4). For every increase in square millimeter of optic disc area, mean RNFL thickness increased by approximately 3.3 μm (95% CI, 0.6-5.6). Comparisons between ethnic groups revealed that Caucasians had mean RNFL values (98.1±10.9 μm) slightly thinner than those of Hispanics (103.7±11.6 μm; P = 0.022) or Asians (105.8±9.2 μm; P = 0.043). There was no relationship between RNFL thickness and eye or gender. Conclusions: Retinal nerve fiber layer thickness, as measured by Stratus OCT, varies significantly with age, ethnicity, axial length, and optic disc area. These variables may need to be taken into account when evaluating patients for diagnosis and follow-up of glaucoma, particularly at the lower boundary of the normal range. Due to the relatively small numbers of subjects of Asian and African descent in the normative database, conclusions regarding the effect of ethnicity should be interpreted with caution.

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