Determination of a clinical value for the repair half-time (T 1/2) of the trigeminal nerve based on outcome data from gamma knife radiosurgery for facial pain

Volker Stieber, Michael Robbins, Christopher Balamucki, Allan DeGuzman, Stephen Tatter, Kenneth Ekstrand, Kevin McMullen, Charles Branch, Edward Shaw, J. Daniel Bourland, James Lovato, Michael Munleya, Thomas Ellis

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2 Scopus citations

Abstract

Stereotactic radiosurgery (GKRS) using the Leksell Gamma Knife is a treatment option for patients with trigeminal pain. We analyzed a database of 326 GKRS procedures performed over 4.6 years at three discrete dose levels commonly described in the published literature. Logistic regression was used to model the logit of response as a function of treatment time. The resulting coefficient was converted to an estimated probability of response for the shortest and longest treatment times in clinical practice. The two estimated probabilities were then compared to yield the estimated difference in the biologically effective dose (BED) between the two doses, using a modified linear-quadratic model for stereotactic radiosurgery. This difference was used to back-calculate a clinical value for T1/2, resulting in a range of 1.28-1.77 h for T1/2. The biological model appeared to accurately predict that, given the doses and treatment times used in general clinical practice, there would be no significant difference in clinical outcome.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalRadiation research
Volume168
Issue number2
DOIs
StatePublished - Aug 1 2007

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ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Stieber, V., Robbins, M., Balamucki, C., DeGuzman, A., Tatter, S., Ekstrand, K., McMullen, K., Branch, C., Shaw, E., Bourland, J. D., Lovato, J., Munleya, M., & Ellis, T. (2007). Determination of a clinical value for the repair half-time (T 1/2) of the trigeminal nerve based on outcome data from gamma knife radiosurgery for facial pain. Radiation research, 168(2), 143-148. https://doi.org/10.1667/RR0620.1