Determination of Bone Age in Children with Cartilaginous Dysplasia (Multiple Hereditary Osteochondromatosis and Ollier's Enchondromatosis)

Randall Loder, Stephen Sundberg, Keith Gabriel, Amir Mehbod, Christopher Meyer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cartilaginous dysplasias (multiple hereditary osteochondromatosis [MHO] and Ollier's enchondromatosis [OE]) are common pediatric orthopaedic conditions. Long bone growth deformities commonly develop in children with MHO and OE. The timing of procedures frequently used to treat these deformities is often dependent upon the bone age. It was the purpose of this study to investigate bone ages in a series of 40 children with MHO and OE. There were 6 girls and 9 boys with OE, and 9 girls and 16 boys with MHO. Each child's age, gender, race, and diagnosis were recorded. Handwrist radiographs obtained during routine evaluation of hand-wrist deformities or scanograms were identified, randomly numbered, and blinded regarding the identity and age of the child. Each radiograph was reviewed by five different observers at two different times separated by a minimum of 3 weeks. Statistical analyses were performed, looking at differences between bone and chronological age; inter- and intraobserver variability in bone age assessment; and differences by observer. The average chronological age (n = 40) was 7.8 ± 3.6 years, average bone age (n = 400) was 7.2 ± 3.7 years, and average difference between chronological and bone age (n = 400) was 0.6 ± 1.3 years (P < 10-6). Intra- and interobserver variability was ±1.5 and ±1.6 years. There were no differences between observers in the average chronological/bone age difference (P = 0.63). Clinicians should be aware of this average 0.6-year delay in bone age when planning an epiphysiodesis for limb length equalization in children with cartilaginous dysplasias.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalJournal of Pediatric Orthopaedics
Volume24
Issue number1
StatePublished - Jan 2004

Fingerprint

Enchondromatosis
Multiple Hereditary Exostoses
Bone and Bones
Observer Variation
Hand Deformities
Bone Development
Wrist
Orthopedics
Extremities
Pediatrics

Keywords

  • Bone age
  • Enchondromatosis
  • Limb length
  • Multiple hereditary osteochondromatosis
  • Observer variability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Determination of Bone Age in Children with Cartilaginous Dysplasia (Multiple Hereditary Osteochondromatosis and Ollier's Enchondromatosis). / Loder, Randall; Sundberg, Stephen; Gabriel, Keith; Mehbod, Amir; Meyer, Christopher.

In: Journal of Pediatric Orthopaedics, Vol. 24, No. 1, 01.2004, p. 102-108.

Research output: Contribution to journalArticle

@article{41c9fc2db4194365b1471a6d40e7c789,
title = "Determination of Bone Age in Children with Cartilaginous Dysplasia (Multiple Hereditary Osteochondromatosis and Ollier's Enchondromatosis)",
abstract = "Cartilaginous dysplasias (multiple hereditary osteochondromatosis [MHO] and Ollier's enchondromatosis [OE]) are common pediatric orthopaedic conditions. Long bone growth deformities commonly develop in children with MHO and OE. The timing of procedures frequently used to treat these deformities is often dependent upon the bone age. It was the purpose of this study to investigate bone ages in a series of 40 children with MHO and OE. There were 6 girls and 9 boys with OE, and 9 girls and 16 boys with MHO. Each child's age, gender, race, and diagnosis were recorded. Handwrist radiographs obtained during routine evaluation of hand-wrist deformities or scanograms were identified, randomly numbered, and blinded regarding the identity and age of the child. Each radiograph was reviewed by five different observers at two different times separated by a minimum of 3 weeks. Statistical analyses were performed, looking at differences between bone and chronological age; inter- and intraobserver variability in bone age assessment; and differences by observer. The average chronological age (n = 40) was 7.8 ± 3.6 years, average bone age (n = 400) was 7.2 ± 3.7 years, and average difference between chronological and bone age (n = 400) was 0.6 ± 1.3 years (P < 10-6). Intra- and interobserver variability was ±1.5 and ±1.6 years. There were no differences between observers in the average chronological/bone age difference (P = 0.63). Clinicians should be aware of this average 0.6-year delay in bone age when planning an epiphysiodesis for limb length equalization in children with cartilaginous dysplasias.",
keywords = "Bone age, Enchondromatosis, Limb length, Multiple hereditary osteochondromatosis, Observer variability",
author = "Randall Loder and Stephen Sundberg and Keith Gabriel and Amir Mehbod and Christopher Meyer",
year = "2004",
month = "1",
language = "English",
volume = "24",
pages = "102--108",
journal = "Journal of Pediatric Orthopaedics",
issn = "0271-6798",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Determination of Bone Age in Children with Cartilaginous Dysplasia (Multiple Hereditary Osteochondromatosis and Ollier's Enchondromatosis)

AU - Loder, Randall

AU - Sundberg, Stephen

AU - Gabriel, Keith

AU - Mehbod, Amir

AU - Meyer, Christopher

PY - 2004/1

Y1 - 2004/1

N2 - Cartilaginous dysplasias (multiple hereditary osteochondromatosis [MHO] and Ollier's enchondromatosis [OE]) are common pediatric orthopaedic conditions. Long bone growth deformities commonly develop in children with MHO and OE. The timing of procedures frequently used to treat these deformities is often dependent upon the bone age. It was the purpose of this study to investigate bone ages in a series of 40 children with MHO and OE. There were 6 girls and 9 boys with OE, and 9 girls and 16 boys with MHO. Each child's age, gender, race, and diagnosis were recorded. Handwrist radiographs obtained during routine evaluation of hand-wrist deformities or scanograms were identified, randomly numbered, and blinded regarding the identity and age of the child. Each radiograph was reviewed by five different observers at two different times separated by a minimum of 3 weeks. Statistical analyses were performed, looking at differences between bone and chronological age; inter- and intraobserver variability in bone age assessment; and differences by observer. The average chronological age (n = 40) was 7.8 ± 3.6 years, average bone age (n = 400) was 7.2 ± 3.7 years, and average difference between chronological and bone age (n = 400) was 0.6 ± 1.3 years (P < 10-6). Intra- and interobserver variability was ±1.5 and ±1.6 years. There were no differences between observers in the average chronological/bone age difference (P = 0.63). Clinicians should be aware of this average 0.6-year delay in bone age when planning an epiphysiodesis for limb length equalization in children with cartilaginous dysplasias.

AB - Cartilaginous dysplasias (multiple hereditary osteochondromatosis [MHO] and Ollier's enchondromatosis [OE]) are common pediatric orthopaedic conditions. Long bone growth deformities commonly develop in children with MHO and OE. The timing of procedures frequently used to treat these deformities is often dependent upon the bone age. It was the purpose of this study to investigate bone ages in a series of 40 children with MHO and OE. There were 6 girls and 9 boys with OE, and 9 girls and 16 boys with MHO. Each child's age, gender, race, and diagnosis were recorded. Handwrist radiographs obtained during routine evaluation of hand-wrist deformities or scanograms were identified, randomly numbered, and blinded regarding the identity and age of the child. Each radiograph was reviewed by five different observers at two different times separated by a minimum of 3 weeks. Statistical analyses were performed, looking at differences between bone and chronological age; inter- and intraobserver variability in bone age assessment; and differences by observer. The average chronological age (n = 40) was 7.8 ± 3.6 years, average bone age (n = 400) was 7.2 ± 3.7 years, and average difference between chronological and bone age (n = 400) was 0.6 ± 1.3 years (P < 10-6). Intra- and interobserver variability was ±1.5 and ±1.6 years. There were no differences between observers in the average chronological/bone age difference (P = 0.63). Clinicians should be aware of this average 0.6-year delay in bone age when planning an epiphysiodesis for limb length equalization in children with cartilaginous dysplasias.

KW - Bone age

KW - Enchondromatosis

KW - Limb length

KW - Multiple hereditary osteochondromatosis

KW - Observer variability

UR - http://www.scopus.com/inward/record.url?scp=0346158562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346158562&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 102

EP - 108

JO - Journal of Pediatric Orthopaedics

JF - Journal of Pediatric Orthopaedics

SN - 0271-6798

IS - 1

ER -