Developing Drugs for Core Social and Communication Impairment in Autism

David J. Posey, Craig A. Erickson, Christopher J. McDougle

Research output: Contribution to journalReview article

48 Scopus citations


There are many challenges to studying drug effects on core social and language impairment in autism. Drugs such as fenfluramine, naltrexone, and secretin do not appear to be efficacious for these core symptoms. Risperidone has led to improvement in some aspects of social relatedness when used to treat irritability in autism. More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms.

Original languageEnglish (US)
Pages (from-to)787-801
Number of pages15
JournalChild and Adolescent Psychiatric Clinics of North America
Issue number4
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

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