Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial

Diane R. Blake, Celeste A. Lemay, Louise S. Maranda, J. Fortenberry, Margaret H. Kearney, Kathleen M. Mazor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

HIV vaccine trials with minors will likely require parental permission and informed assent from adolescents. For this to be a valid process, the information needs to be presented in a manner that promotes adolescent comprehension. Previous studies suggest that adolescent comprehension of assent is often insufficient. We developed an interactive web-based assent that included interspersed quiz questions for a hypothetical HIV vaccine trial. Efficacy of the web-based assent was compared to a standard paper assent with and without interspersed questions. One hundred twenty teen participants, ages 15-17 years, from five community organizations were randomized to self-administered web-based assent (n = 60) or investigator-administered paper assent with (n = 29) or without (n = 31) interspersed quiz questions. After reviewing the assent, participants completed a 27-item comprehension test. Comprehension scores were compared between groups. The mean number of correctly answered questions were 21.2 for the full paper group and 21.1 for the web-based group (t118 = -0.08, p = 0.94). Scores were 20.2 for the paper without interspersed questions sub-group and 22.1 for the paper with interspersed questions sub-group (t58 = 1.96, p = 0.055). Participants in the web-based group performed as well on the comprehension test as those in the paper group, and those in the paper with questions sub-group performed better than those in the paper without questions sub-group, suggesting that interspersed quiz questions may improve understanding of a traditional paper assent. The minimal investigator time and standardized administration of the web-based assent as well as ability to tailor the assent discussion to topics identified by incorrect comprehension test responses are advantages worthy of further investigation.

Original languageEnglish (US)
Pages (from-to)1005-1013
Number of pages9
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume27
Issue number8
DOIs
StatePublished - Aug 3 2015

Fingerprint

AIDS Vaccines
adolescent
comprehension
evaluation
Group
quiz
Research Personnel
Minors
Aptitude
Organizations

Keywords

  • adolescence
  • clinical trials
  • computer-assisted instruction
  • HIV infection and AIDS
  • informed consent
  • research ethics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Social Psychology

Cite this

Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial. / Blake, Diane R.; Lemay, Celeste A.; Maranda, Louise S.; Fortenberry, J.; Kearney, Margaret H.; Mazor, Kathleen M.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Vol. 27, No. 8, 03.08.2015, p. 1005-1013.

Research output: Contribution to journalArticle

Blake, Diane R. ; Lemay, Celeste A. ; Maranda, Louise S. ; Fortenberry, J. ; Kearney, Margaret H. ; Mazor, Kathleen M. / Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial. In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV. 2015 ; Vol. 27, No. 8. pp. 1005-1013.
@article{71997ca0f2da46c5a0f5df024e0151e7,
title = "Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial",
abstract = "HIV vaccine trials with minors will likely require parental permission and informed assent from adolescents. For this to be a valid process, the information needs to be presented in a manner that promotes adolescent comprehension. Previous studies suggest that adolescent comprehension of assent is often insufficient. We developed an interactive web-based assent that included interspersed quiz questions for a hypothetical HIV vaccine trial. Efficacy of the web-based assent was compared to a standard paper assent with and without interspersed questions. One hundred twenty teen participants, ages 15-17 years, from five community organizations were randomized to self-administered web-based assent (n = 60) or investigator-administered paper assent with (n = 29) or without (n = 31) interspersed quiz questions. After reviewing the assent, participants completed a 27-item comprehension test. Comprehension scores were compared between groups. The mean number of correctly answered questions were 21.2 for the full paper group and 21.1 for the web-based group (t118 = -0.08, p = 0.94). Scores were 20.2 for the paper without interspersed questions sub-group and 22.1 for the paper with interspersed questions sub-group (t58 = 1.96, p = 0.055). Participants in the web-based group performed as well on the comprehension test as those in the paper group, and those in the paper with questions sub-group performed better than those in the paper without questions sub-group, suggesting that interspersed quiz questions may improve understanding of a traditional paper assent. The minimal investigator time and standardized administration of the web-based assent as well as ability to tailor the assent discussion to topics identified by incorrect comprehension test responses are advantages worthy of further investigation.",
keywords = "adolescence, clinical trials, computer-assisted instruction, HIV infection and AIDS, informed consent, research ethics",
author = "Blake, {Diane R.} and Lemay, {Celeste A.} and Maranda, {Louise S.} and J. Fortenberry and Kearney, {Margaret H.} and Mazor, {Kathleen M.}",
year = "2015",
month = "8",
day = "3",
doi = "10.1080/09540121.2015.1024096",
language = "English (US)",
volume = "27",
pages = "1005--1013",
journal = "AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV",
issn = "0954-0121",
publisher = "Routledge",
number = "8",

}

TY - JOUR

T1 - Development and evaluation of a web-based assent for adolescents considering an HIV vaccine trial

AU - Blake, Diane R.

AU - Lemay, Celeste A.

AU - Maranda, Louise S.

AU - Fortenberry, J.

AU - Kearney, Margaret H.

AU - Mazor, Kathleen M.

PY - 2015/8/3

Y1 - 2015/8/3

N2 - HIV vaccine trials with minors will likely require parental permission and informed assent from adolescents. For this to be a valid process, the information needs to be presented in a manner that promotes adolescent comprehension. Previous studies suggest that adolescent comprehension of assent is often insufficient. We developed an interactive web-based assent that included interspersed quiz questions for a hypothetical HIV vaccine trial. Efficacy of the web-based assent was compared to a standard paper assent with and without interspersed questions. One hundred twenty teen participants, ages 15-17 years, from five community organizations were randomized to self-administered web-based assent (n = 60) or investigator-administered paper assent with (n = 29) or without (n = 31) interspersed quiz questions. After reviewing the assent, participants completed a 27-item comprehension test. Comprehension scores were compared between groups. The mean number of correctly answered questions were 21.2 for the full paper group and 21.1 for the web-based group (t118 = -0.08, p = 0.94). Scores were 20.2 for the paper without interspersed questions sub-group and 22.1 for the paper with interspersed questions sub-group (t58 = 1.96, p = 0.055). Participants in the web-based group performed as well on the comprehension test as those in the paper group, and those in the paper with questions sub-group performed better than those in the paper without questions sub-group, suggesting that interspersed quiz questions may improve understanding of a traditional paper assent. The minimal investigator time and standardized administration of the web-based assent as well as ability to tailor the assent discussion to topics identified by incorrect comprehension test responses are advantages worthy of further investigation.

AB - HIV vaccine trials with minors will likely require parental permission and informed assent from adolescents. For this to be a valid process, the information needs to be presented in a manner that promotes adolescent comprehension. Previous studies suggest that adolescent comprehension of assent is often insufficient. We developed an interactive web-based assent that included interspersed quiz questions for a hypothetical HIV vaccine trial. Efficacy of the web-based assent was compared to a standard paper assent with and without interspersed questions. One hundred twenty teen participants, ages 15-17 years, from five community organizations were randomized to self-administered web-based assent (n = 60) or investigator-administered paper assent with (n = 29) or without (n = 31) interspersed quiz questions. After reviewing the assent, participants completed a 27-item comprehension test. Comprehension scores were compared between groups. The mean number of correctly answered questions were 21.2 for the full paper group and 21.1 for the web-based group (t118 = -0.08, p = 0.94). Scores were 20.2 for the paper without interspersed questions sub-group and 22.1 for the paper with interspersed questions sub-group (t58 = 1.96, p = 0.055). Participants in the web-based group performed as well on the comprehension test as those in the paper group, and those in the paper with questions sub-group performed better than those in the paper without questions sub-group, suggesting that interspersed quiz questions may improve understanding of a traditional paper assent. The minimal investigator time and standardized administration of the web-based assent as well as ability to tailor the assent discussion to topics identified by incorrect comprehension test responses are advantages worthy of further investigation.

KW - adolescence

KW - clinical trials

KW - computer-assisted instruction

KW - HIV infection and AIDS

KW - informed consent

KW - research ethics

UR - http://www.scopus.com/inward/record.url?scp=84929268832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929268832&partnerID=8YFLogxK

U2 - 10.1080/09540121.2015.1024096

DO - 10.1080/09540121.2015.1024096

M3 - Article

C2 - 25803694

AN - SCOPUS:84929268832

VL - 27

SP - 1005

EP - 1013

JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV

JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV

SN - 0954-0121

IS - 8

ER -