Development and functional characterization of T cell lines from canine Peyer's patches

H. Hogenesch, P. J. Felsburg

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have propagated concanavalin A-stimulated cells from canine Peyer's patches in vitro in the presence of interleukin-2 (IL-2). The cells were characterized as T cells by determination of their phenotype and by functional assays. They are IL-2 dependent and respond to IL-2 of murine, primate and canine origin. The long-term cultured cells provided help for immunoglobulin production by purified autologous B cells and suppressed IgG production by nonseparated autologous peripheral blood mononuclear cells.

Original languageEnglish (US)
Pages (from-to)29-39
Number of pages11
JournalVeterinary Immunology and Immunopathology
Volume23
Issue number1-2
DOIs
StatePublished - Nov 30 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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