Development of a stroke-specific quality of life scale

Linda S. Williams, Morris Weinberger, Lisa E. Harris, Daniel O. Clark, José Biller

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

Background and Purpose - Clinical stroke trials are increasingly measuring patient-centered outcomes such as functional status and health- related quality of life (HRQOL). No stroke-specific HRQOL measure is currently available. This study presents the initial development of a valid, reliable, and responsive stroke-specific quality of life (SS-QOL) measure, for use in stroke trials. Methods - Domains and items for the SS-QOL were developed from patient interviews. The SS-QOL, Short Form 36, Beck Depression Inventory, National Institutes of Health Stroke Scale, and Barthel Index were administered to patients 1 and 3 months after ischemic stroke. Items were eliminated with the use of standard psychometric criteria. Construct validity was assessed by comparing domain scores with similar domains of established measures. Domain responsiveness was assessed with standardized effect sizes. Results - All 12 domains of the SS-QOL were unidimensional. In the final 49- item scale, all domains demonstrated excellent internal reliability (Cronbach's α values for each domain ≥0.73). Most domains were moderately correlated with similar domains of established outcome measures (r2 range, 0.3 to 0.5). Most domains were responsive to change (standardized effect sizes >0.4). One- and 3-month SS-QOL scores were associated with patients' self report of HRQOL compared with before their stroke (P<O.001). Conclusions - The SS-QOL measures HRQOL, its primary underlying construct, in stroke patients. Preliminary results regarding the reliability, validity, and responsiveness of the SS-QOL are encouraging. Further studies in diverse stroke populations are needed.

Original languageEnglish (US)
Pages (from-to)1362-1369
Number of pages8
JournalStroke
Volume30
Issue number7
DOIs
StatePublished - Jul 1999

Fingerprint

Stroke
Quality of Life
National Institutes of Health (U.S.)
Psychometrics
Reproducibility of Results
Self Report
Outcome Assessment (Health Care)
Clinical Trials
Interviews
Depression
Equipment and Supplies

Keywords

  • Cerebral infarction
  • Outcome
  • Quality of life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Development of a stroke-specific quality of life scale. / Williams, Linda S.; Weinberger, Morris; Harris, Lisa E.; Clark, Daniel O.; Biller, José.

In: Stroke, Vol. 30, No. 7, 07.1999, p. 1362-1369.

Research output: Contribution to journalArticle

Williams, LS, Weinberger, M, Harris, LE, Clark, DO & Biller, J 1999, 'Development of a stroke-specific quality of life scale', Stroke, vol. 30, no. 7, pp. 1362-1369. https://doi.org/10.1161/01.STR.30.7.1362
Williams, Linda S. ; Weinberger, Morris ; Harris, Lisa E. ; Clark, Daniel O. ; Biller, José. / Development of a stroke-specific quality of life scale. In: Stroke. 1999 ; Vol. 30, No. 7. pp. 1362-1369.
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