Development of contrast enhanced rodent imaging using functional CT

Yun Liang, Keith M. Stantz, Ganapathy Krishnamurthi, Rosemary Steinmetz, Gary Hutchins

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Micro-computed tomography (microCT) is capable of obtaining high-resolution images of skeletal tissues. However its image contrast among soft tissues remains inadequate for tumor detection. High speed functional computed tomography will be needed to image tumors by employing x-ray contrast medium. The functional microCT development will not only facilitate the image contrast enhancement among different tissues but also provide information of tumor physiology. To demonstrate the feasibility of functional CT in mouse imaging, sequential computed tomography is performed in mice after contrast material administration using a high- speed clinical CT scanner. Although the resolution of the clinical scanner is not sufficient to dissolve the anatomic details of rodents, bulky physiological parameters in major organs such as liver, kidney, pancreas, and ovaries (testicular) can be examined. For data analysis, a two-compartmental model is employed and implemented to characterize the tissue physiological parameters (regional blood flow, capillary permeability, and relative compartment volumes.) The measured contrast dynamics in kidneys are fitted with the compartmental model to derive the kidney tissue physiology. The study result suggests that it is feasible to extract mouse tissue physiology using functional CT imaging technology.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.V. Clough, A.A. Amini
Number of pages9
StatePublished - 2003
EventMedical Imaging 2003: Physiology and Function: Methods, Systems, and Applications - San Diego, CA, United States
Duration: Feb 16 2003Feb 18 2003


OtherMedical Imaging 2003: Physiology and Function: Methods, Systems, and Applications
CountryUnited States
CitySan Diego, CA

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Development of contrast enhanced rodent imaging using functional CT'. Together they form a unique fingerprint.

Cite this