Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse

Nabeshima Toshitaka, Subbiah Sivam, Christine Y. Tai, Ing K. Ho

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. The implantation of a PCP (1-3 mg/ day/mouse for 1-5 days)-containing osmotic minipump, induced tolerance, as evidenced by a gradual reduction of the duration of motor incoordination. The degree of tolerance exhibited dose and time dependency. Even after the removal of the PCP pump (1 mg/day/mouse for 5 days), the tolerance remained to the same degree for at least 4 days. The hepatic microsomal cytochrome P-450, cytochrome b5 and nicotinamide adenine dinucleotide phosphatase (NADPH)-cyctochrome c reductase activities were found to be elevated in tolerant mice (2 mg/ day/mouse for 5 days). The half-life of PCP in the brains of tolerant mice was likewise decreased. These data indicate a dispositional tolerance for PCP. It appears that the administration of PCP by the osmotic minipump offers a convenient method for inducing PCP tolerance.

Original languageEnglish (US)
Pages (from-to)239-253
Number of pages15
JournalJournal of Pharmacological Methods
Volume7
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Phencyclidine
Ataxia
Cytochromes b5
Inbred ICR Mouse
Phosphoric Monoester Hydrolases
NAD
Cytochrome P-450 Enzyme System
Half-Life
Oxidoreductases
Brain
Pumps
Liver

Keywords

  • Cytochrome P-450
  • Half-life
  • Motor incoordination
  • Osmotic minipump
  • Phencyclidine
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology

Cite this

Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse. / Toshitaka, Nabeshima; Sivam, Subbiah; Tai, Christine Y.; Ho, Ing K.

In: Journal of Pharmacological Methods, Vol. 7, No. 3, 1982, p. 239-253.

Research output: Contribution to journalArticle

Toshitaka, Nabeshima ; Sivam, Subbiah ; Tai, Christine Y. ; Ho, Ing K. / Development of dispositional tolerance to phencyclidine by osmotic minipump in the mouse. In: Journal of Pharmacological Methods. 1982 ; Vol. 7, No. 3. pp. 239-253.
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