Development of pulmonary hypertension in an infant treated with diazoxide

Todd D. Nebesio, Wynton C. Hoover, Randall L. Caldwell, Mara E. Nitu, Erica A. Eugster

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Diazoxide is commonly used in the treatment of neonatal hyperinsulinism. We describe a one month-old infant who was treated with diazoxide for prolonged neonatal hyperinsulinism. Shortly after starting diazoxide, she was admitted to the hospital for tachypnea with hypoxemia, and was subsequently diagnosed with laryngomalacia and obstructive apnea. During hospitalization, her clinical course worsened due to the development of severe pulmonary hypertension, presumed due to diazoxide toxicity. Lung biopsy revealed a probable toxic vascular drug reaction. After discontinuing diazoxide, her clinical status improved and eventually returned to baseline.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume20
Issue number8
DOIs
StatePublished - Aug 2007

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Keywords

  • Hypoglycemia
  • Pulmonary hypertension
  • SUR
  • Toxicity

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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