Development of the International Thymic Malignancy Interest Group International Database: An unprecedented resource for the study of a rare group of tumors

James Huang, Usman Ahmad, Alberto Antonicelli, Ann Christine Catlin, Wentao Fang, Daniel Gomez, Patrick Loehrer, Marco Lucchi, Edith Marom, Andrew Nicholson, Enrico Ruffini, William Travis, Paul Van Schil, Heather Wakelee, Xiaopan Yao, Frank Detterbeck

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Our knowledge of thymic malignancies has largely been derived from small, single-institution series. Recognition of the need for broad collaboration led to the creation of the International Thymic Malignancy Interest Group (ITMIG) and the development of a large, centralized database to advance knowledge of these rare tumors. Methods: A multidisciplinary Database Committee was convened to define a common set of data elements a priori. Retrospective data were solicited from ITMIG members and collated using standardized fields. Patients with thymoma, thymic carcinoma, or thymic carcinoid were included. Results: Over a 6-month period, 47 institutions spanning 15 countries contributed a total of 6097 cases (mean, 129 [range, 10-1209]). The sex distribution was equal for thymomas, but there was a greater proportion of men with thymic carcinoma and thymic carcinoid (p <0.0001). Nearly all cases (99%) were treated surgically. WHO type B2 was the most frequent histologic classification among thymomas, whereas squamous was the most common among thymic carcinomas. In total, 38% of patients with thymoma had myasthenia gravis compared with less than or equal to 5% for thymic carcinoma and thymic carcinoid. Median overall survival was 18.9 years (95% confidence interval [CI], 17.4-20.3) for thymoma, 6.8 years (95% CI, 5.5-7.9) for thymic carcinoma, and 7.5 years (95% CI, 6.5-8.5) for thymic carcinoid. Conclusions: The rapid creation of the ITMIG database demonstrates the feasibility of international collaboration for this rare set of malignancies and attests to the engagement of its membership. This database represents the largest collective data set ever assembled and provides an unprecedented resource for research of these tumors.

Original languageEnglish (US)
Pages (from-to)1573-1578
Number of pages6
JournalJournal of Thoracic Oncology
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2014

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Public Opinion
Thymoma
Databases
Carcinoid Tumor
Neoplasms
Confidence Intervals
Sex Distribution
Myasthenia Gravis

Keywords

  • Database
  • Thymic carcinoid
  • Thymic carcinoma
  • Thymic malignancies
  • Thymoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Development of the International Thymic Malignancy Interest Group International Database : An unprecedented resource for the study of a rare group of tumors. / Huang, James; Ahmad, Usman; Antonicelli, Alberto; Catlin, Ann Christine; Fang, Wentao; Gomez, Daniel; Loehrer, Patrick; Lucchi, Marco; Marom, Edith; Nicholson, Andrew; Ruffini, Enrico; Travis, William; Van Schil, Paul; Wakelee, Heather; Yao, Xiaopan; Detterbeck, Frank.

In: Journal of Thoracic Oncology, Vol. 9, No. 10, 01.10.2014, p. 1573-1578.

Research output: Contribution to journalArticle

Huang, J, Ahmad, U, Antonicelli, A, Catlin, AC, Fang, W, Gomez, D, Loehrer, P, Lucchi, M, Marom, E, Nicholson, A, Ruffini, E, Travis, W, Van Schil, P, Wakelee, H, Yao, X & Detterbeck, F 2014, 'Development of the International Thymic Malignancy Interest Group International Database: An unprecedented resource for the study of a rare group of tumors', Journal of Thoracic Oncology, vol. 9, no. 10, pp. 1573-1578. https://doi.org/10.1097/JTO.0000000000000269
Huang, James ; Ahmad, Usman ; Antonicelli, Alberto ; Catlin, Ann Christine ; Fang, Wentao ; Gomez, Daniel ; Loehrer, Patrick ; Lucchi, Marco ; Marom, Edith ; Nicholson, Andrew ; Ruffini, Enrico ; Travis, William ; Van Schil, Paul ; Wakelee, Heather ; Yao, Xiaopan ; Detterbeck, Frank. / Development of the International Thymic Malignancy Interest Group International Database : An unprecedented resource for the study of a rare group of tumors. In: Journal of Thoracic Oncology. 2014 ; Vol. 9, No. 10. pp. 1573-1578.
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abstract = "Background: Our knowledge of thymic malignancies has largely been derived from small, single-institution series. Recognition of the need for broad collaboration led to the creation of the International Thymic Malignancy Interest Group (ITMIG) and the development of a large, centralized database to advance knowledge of these rare tumors. Methods: A multidisciplinary Database Committee was convened to define a common set of data elements a priori. Retrospective data were solicited from ITMIG members and collated using standardized fields. Patients with thymoma, thymic carcinoma, or thymic carcinoid were included. Results: Over a 6-month period, 47 institutions spanning 15 countries contributed a total of 6097 cases (mean, 129 [range, 10-1209]). The sex distribution was equal for thymomas, but there was a greater proportion of men with thymic carcinoma and thymic carcinoid (p <0.0001). Nearly all cases (99{\%}) were treated surgically. WHO type B2 was the most frequent histologic classification among thymomas, whereas squamous was the most common among thymic carcinomas. In total, 38{\%} of patients with thymoma had myasthenia gravis compared with less than or equal to 5{\%} for thymic carcinoma and thymic carcinoid. Median overall survival was 18.9 years (95{\%} confidence interval [CI], 17.4-20.3) for thymoma, 6.8 years (95{\%} CI, 5.5-7.9) for thymic carcinoma, and 7.5 years (95{\%} CI, 6.5-8.5) for thymic carcinoid. Conclusions: The rapid creation of the ITMIG database demonstrates the feasibility of international collaboration for this rare set of malignancies and attests to the engagement of its membership. This database represents the largest collective data set ever assembled and provides an unprecedented resource for research of these tumors.",
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AU - Ruffini, Enrico

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