Developmental plasticity of reticulospinal and vestibulospinal axons in the North American opossum, Didelphis virginiana

X. M. Wang, Y. Q. Qin, Xiao-Ming Xu, G. F. Martin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have shown previously that rubral axons grow around a lesion of their spinal pathway in the North American opossum if it is made at early stages of development. In the present experiments, we have asked whether reticular and vestibular axons have the same ability. The spinal cord was hemisected at postnatal day 20, 12, or 5, well within the critical period for rubrospinal plasticity, and, approximately 30 days later, bilateral injections of fast blue were made about four segments caudal to the lesion. The pups were killed 4 or 5 days after the injections. In most of the animals lesioned on postnatal day 20, labeled neurons were not found in the medial part of the pontine reticular nucleus or the dorsal part of the lateral vestibular nucleus ipsilateral to the lesion. The spinal projections from both areas are exclusively ipsilateral. When the lesions were made at postnatal day 12 or 5, however, labeled neurons were present in both areas, suggesting that they supported axons that had grown caudal to the lesion. As was expected from previous studies, rubral neurons were labeled contralateral to the lesion in all three groups. In the opossum, as in other species, the red nucleus projects contralaterally. We conclude that reticular and vestibular axons, like axons from the red nucleus, grow around a lesion of their pathway during development and that the critical period for their plasticity ends earlier than that for rubrospinal axons.

Original languageEnglish (US)
Pages (from-to)288-302
Number of pages15
JournalJournal of Comparative Neurology
Volume349
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Didelphis
Axons
Red Nucleus
Neurons
Lateral Vestibular Nucleus
Opossums
Injections
Spinal Cord

Keywords

  • axotomy
  • brainstem
  • marsupial
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Developmental plasticity of reticulospinal and vestibulospinal axons in the North American opossum, Didelphis virginiana. / Wang, X. M.; Qin, Y. Q.; Xu, Xiao-Ming; Martin, G. F.

In: Journal of Comparative Neurology, Vol. 349, No. 2, 1994, p. 288-302.

Research output: Contribution to journalArticle

@article{8b9e6851f2384512a4bc9d1dc1f881cf,
title = "Developmental plasticity of reticulospinal and vestibulospinal axons in the North American opossum, Didelphis virginiana",
abstract = "We have shown previously that rubral axons grow around a lesion of their spinal pathway in the North American opossum if it is made at early stages of development. In the present experiments, we have asked whether reticular and vestibular axons have the same ability. The spinal cord was hemisected at postnatal day 20, 12, or 5, well within the critical period for rubrospinal plasticity, and, approximately 30 days later, bilateral injections of fast blue were made about four segments caudal to the lesion. The pups were killed 4 or 5 days after the injections. In most of the animals lesioned on postnatal day 20, labeled neurons were not found in the medial part of the pontine reticular nucleus or the dorsal part of the lateral vestibular nucleus ipsilateral to the lesion. The spinal projections from both areas are exclusively ipsilateral. When the lesions were made at postnatal day 12 or 5, however, labeled neurons were present in both areas, suggesting that they supported axons that had grown caudal to the lesion. As was expected from previous studies, rubral neurons were labeled contralateral to the lesion in all three groups. In the opossum, as in other species, the red nucleus projects contralaterally. We conclude that reticular and vestibular axons, like axons from the red nucleus, grow around a lesion of their pathway during development and that the critical period for their plasticity ends earlier than that for rubrospinal axons.",
keywords = "axotomy, brainstem, marsupial, spinal cord",
author = "Wang, {X. M.} and Qin, {Y. Q.} and Xiao-Ming Xu and Martin, {G. F.}",
year = "1994",
doi = "10.1002/cne.903490210",
language = "English (US)",
volume = "349",
pages = "288--302",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Developmental plasticity of reticulospinal and vestibulospinal axons in the North American opossum, Didelphis virginiana

AU - Wang, X. M.

AU - Qin, Y. Q.

AU - Xu, Xiao-Ming

AU - Martin, G. F.

PY - 1994

Y1 - 1994

N2 - We have shown previously that rubral axons grow around a lesion of their spinal pathway in the North American opossum if it is made at early stages of development. In the present experiments, we have asked whether reticular and vestibular axons have the same ability. The spinal cord was hemisected at postnatal day 20, 12, or 5, well within the critical period for rubrospinal plasticity, and, approximately 30 days later, bilateral injections of fast blue were made about four segments caudal to the lesion. The pups were killed 4 or 5 days after the injections. In most of the animals lesioned on postnatal day 20, labeled neurons were not found in the medial part of the pontine reticular nucleus or the dorsal part of the lateral vestibular nucleus ipsilateral to the lesion. The spinal projections from both areas are exclusively ipsilateral. When the lesions were made at postnatal day 12 or 5, however, labeled neurons were present in both areas, suggesting that they supported axons that had grown caudal to the lesion. As was expected from previous studies, rubral neurons were labeled contralateral to the lesion in all three groups. In the opossum, as in other species, the red nucleus projects contralaterally. We conclude that reticular and vestibular axons, like axons from the red nucleus, grow around a lesion of their pathway during development and that the critical period for their plasticity ends earlier than that for rubrospinal axons.

AB - We have shown previously that rubral axons grow around a lesion of their spinal pathway in the North American opossum if it is made at early stages of development. In the present experiments, we have asked whether reticular and vestibular axons have the same ability. The spinal cord was hemisected at postnatal day 20, 12, or 5, well within the critical period for rubrospinal plasticity, and, approximately 30 days later, bilateral injections of fast blue were made about four segments caudal to the lesion. The pups were killed 4 or 5 days after the injections. In most of the animals lesioned on postnatal day 20, labeled neurons were not found in the medial part of the pontine reticular nucleus or the dorsal part of the lateral vestibular nucleus ipsilateral to the lesion. The spinal projections from both areas are exclusively ipsilateral. When the lesions were made at postnatal day 12 or 5, however, labeled neurons were present in both areas, suggesting that they supported axons that had grown caudal to the lesion. As was expected from previous studies, rubral neurons were labeled contralateral to the lesion in all three groups. In the opossum, as in other species, the red nucleus projects contralaterally. We conclude that reticular and vestibular axons, like axons from the red nucleus, grow around a lesion of their pathway during development and that the critical period for their plasticity ends earlier than that for rubrospinal axons.

KW - axotomy

KW - brainstem

KW - marsupial

KW - spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0027949386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027949386&partnerID=8YFLogxK

U2 - 10.1002/cne.903490210

DO - 10.1002/cne.903490210

M3 - Article

C2 - 7860784

AN - SCOPUS:0027949386

VL - 349

SP - 288

EP - 302

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 2

ER -