Deviations in brain early serotonergic development as a result of fetal alcohol exposure

Feng Zhou, Y. Sari, T. K. Li, C. Goodlett, E. C. Azmitia

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Serotonin (5-HT) has specific roles not only as a transmitter but also as a signal for differentiation. We recently found that alcohol drinking during pregnancy resulted in incomplete neural tube fusion which hindered the development of midline cells such as 5-HT neurons in mice. We now report that, at the birth of 5-HT neurons (E11), the 5-HT immunoreactive (5-HT-im) neurons are often found missing medial projecting fibers towards ventricle in the Alcohol treated group (ALC) as compared with pair-fed (PF) and Chow-fed groups (Chow) in mice. At E13, there are fewer 5-HT-im neurons in either dorsal or median raphe of ALC as compared with PF or Chow; furthermore, neurite outgrowth and migration of the 5-HT neurons are also compromised with alcohol exposure. We, thus, demonstrated that fetal alcohol exposure compromised 5-HT development as early as at the 5-HT neuron birth. Since 5-HT is a signal for development of many forebrain neurons, the deviation of 5-HT in early life may have consequences on brain development that extend beyond those seen in the 5-HT system.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalNeurotoxicity Research
Volume4
Issue number4
DOIs
StatePublished - Jun 2002

Fingerprint

Brain
Serotonin
Alcohols
Neurons
Parturition
Neural Tube
Prosencephalon
Alcohol Drinking
Transmitters
Fusion reactions
Pregnancy
Fibers

Keywords

  • 5-HT fetal alcohol syndrome
  • Fetal alcohol effect
  • Neural tube defect
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Deviations in brain early serotonergic development as a result of fetal alcohol exposure. / Zhou, Feng; Sari, Y.; Li, T. K.; Goodlett, C.; Azmitia, E. C.

In: Neurotoxicity Research, Vol. 4, No. 4, 06.2002, p. 337-342.

Research output: Contribution to journalArticle

Zhou, Feng ; Sari, Y. ; Li, T. K. ; Goodlett, C. ; Azmitia, E. C. / Deviations in brain early serotonergic development as a result of fetal alcohol exposure. In: Neurotoxicity Research. 2002 ; Vol. 4, No. 4. pp. 337-342.
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