Dextroamphetamine infusions in normals result in correlated increases of plasma β-endorphin and cortisol immunoreactivity

Martin R. Cohen, John I. Nurnberger, David Pickar, Elliot Gershon, William E. Bunney

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Stress induces behavioral and hormonal alterations. In experimental and clinical studies, amphetamine administration may simulate or potentiate such effects. The endogenous opioid system has been implicated in the modulation of stress effects. Dextroamphetamine, 0.3 mg./kg. and placebo were infused on separate days in a double-blind cross over design to eight normal volunteers. At 30 minutes post infusion, plasma β-endorphin immunoreactivity was significantly (p < 0.05) increased. The increase ws significantly correlated (r = 0.76, p = 0.05) with volunteers' cortisol responses.

Original languageEnglish (US)
Pages (from-to)1243-1247
Number of pages5
JournalLife Sciences
Volume29
Issue number12
DOIs
StatePublished - Sep 21 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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