Diabetes and depression

Richard I G Holt, Mary de Groot, Sherita Hill Golden

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitaryadrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.

Original languageEnglish
Article number491
JournalCurrent Diabetes Reports
Volume14
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Depression
Psychology
Feeding Behavior
Antidepressive Agents
Psychiatry
Life Style
Sleep
Inflammation

Keywords

  • Depression
  • Diabetes
  • Mechanisms
  • Screening
  • Treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Diabetes and depression. / Holt, Richard I G; de Groot, Mary; Golden, Sherita Hill.

In: Current Diabetes Reports, Vol. 14, No. 6, 491, 2014.

Research output: Contribution to journalArticle

Holt, Richard I G ; de Groot, Mary ; Golden, Sherita Hill. / Diabetes and depression. In: Current Diabetes Reports. 2014 ; Vol. 14, No. 6.
@article{f8ec230b5dd44b3f864949dfde4f44d4,
title = "Diabetes and depression",
abstract = "Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitaryadrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.",
keywords = "Depression, Diabetes, Mechanisms, Screening, Treatment",
author = "Holt, {Richard I G} and {de Groot}, Mary and Golden, {Sherita Hill}",
year = "2014",
doi = "10.1007/s11892-014-0491-3",
language = "English",
volume = "14",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "6",

}

TY - JOUR

T1 - Diabetes and depression

AU - Holt, Richard I G

AU - de Groot, Mary

AU - Golden, Sherita Hill

PY - 2014

Y1 - 2014

N2 - Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitaryadrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.

AB - Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitaryadrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.

KW - Depression

KW - Diabetes

KW - Mechanisms

KW - Screening

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84901577927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901577927&partnerID=8YFLogxK

U2 - 10.1007/s11892-014-0491-3

DO - 10.1007/s11892-014-0491-3

M3 - Article

C2 - 24743941

AN - SCOPUS:84901577927

VL - 14

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 6

M1 - 491

ER -