Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer

Guido Eibl, Zobeida Cruz-Monserrate, Murray Korc, Maxim S. Petrov, Mark O. Goodarzi, William E. Fisher, Aida Habtezion, Aurelia Lugea, Stephen J. Pandol, Phil A. Hart, Dana K. Andersen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030. Considering the failure to date to efficiently treat existing PDAC, increased effort should be undertaken to prevent this disease. A better understanding of the risk factors leading to PDAC development is of utmost importance to identify and formulate preventive strategies. Large epidemiologic and cohort studies have identified risk factors for the development of PDAC, including obesity and type 2 diabetes mellitus. This review highlights the current knowledge of obesity and type 2 diabetes as risk factors for PDAC development and progression, their interplay and underlying mechanisms, and the relation to diet. Research gaps and opportunities to address this deadly disease are also outlined.

Original languageEnglish (US)
JournalJournal of the Academy of Nutrition and Dietetics
DOIs
StateAccepted/In press - 2017
Externally publishedYes

Fingerprint

pancreatic neoplasms
diabetes mellitus
adenocarcinoma
Pancreatic Neoplasms
Diabetes Mellitus
Adenocarcinoma
obesity
risk factors
Obesity
death
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
neoplasms
Incidence
cohort studies
disease incidence
epidemiological studies
Epidemiologic Studies
Neoplasms
Cohort Studies

Keywords

  • Obesity
  • Pancreatic cancer
  • Prevention
  • Review
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Eibl, G., Cruz-Monserrate, Z., Korc, M., Petrov, M. S., Goodarzi, M. O., Fisher, W. E., ... Andersen, D. K. (Accepted/In press). Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. Journal of the Academy of Nutrition and Dietetics. https://doi.org/10.1016/j.jand.2017.07.005

Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. / Eibl, Guido; Cruz-Monserrate, Zobeida; Korc, Murray; Petrov, Maxim S.; Goodarzi, Mark O.; Fisher, William E.; Habtezion, Aida; Lugea, Aurelia; Pandol, Stephen J.; Hart, Phil A.; Andersen, Dana K.

In: Journal of the Academy of Nutrition and Dietetics, 2017.

Research output: Contribution to journalArticle

Eibl, G, Cruz-Monserrate, Z, Korc, M, Petrov, MS, Goodarzi, MO, Fisher, WE, Habtezion, A, Lugea, A, Pandol, SJ, Hart, PA & Andersen, DK 2017, 'Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer', Journal of the Academy of Nutrition and Dietetics. https://doi.org/10.1016/j.jand.2017.07.005
Eibl, Guido ; Cruz-Monserrate, Zobeida ; Korc, Murray ; Petrov, Maxim S. ; Goodarzi, Mark O. ; Fisher, William E. ; Habtezion, Aida ; Lugea, Aurelia ; Pandol, Stephen J. ; Hart, Phil A. ; Andersen, Dana K. / Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. In: Journal of the Academy of Nutrition and Dietetics. 2017.
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