Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to an insufficiency of endogenous insulin secretion or decreased receptor sensitivity to endogenous insulin. In most cases, it is a combination of these defects that leads to the clinical syndrome of diabetes. It has been conservatively estimated by the World Health Organization that worldwide over 300 million people will be affected by diabetes by the year 2030. It is likely the numbers will be far greater. The clinical manifestations of diabetes are as varied as they are debilitating. They can extend from ophthalmological or dermatological manifestations to malignant cardiovascular disease. There continues to be intense research aimed at understanding the pathogenesis of diabetes and its complications. Central to this effort is the understanding of the complex interplay between diabetes and oxidative stress. The goal of this chapter is to summarize the current database on the role of oxidative stress in cardiovascular manifestations of diabetes. We will also discuss some of the existing and novel therapies that target oxidative pathways with regard to diabetes.
|Original language||English (US)|
|Title of host publication||Oxidative Stress|
|Subtitle of host publication||A Focus on Cardiovascular Disease Pathogenesis|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||20|
|State||Published - Dec 1 2011|
ASJC Scopus subject areas