Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis

Steven A. Abrendt, Henry A. Pitt, Attila Nakeeb, Andrew S. Klein, Keith D. Lillemoe, Anthony N. Kalloo, John L. Cameron

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Cholangiocarcinoma remains difficult to diagnose and is a major cause of death in patients with primary sclerosing cholangitis. Recently serum carcinoembryonic antigen and carbohydrate antigen 19-9 (CA 19-9) levels have been reported to improve diagnostic accuracy in patients with cholangiocarcinoma and primary sclerosing cholangitis. We reviewed our experience with cholangiocarcinoma complicating primary sclerosing cholangitis to identify clinical factors associated with cholangiocarcinoma in patients with primary sclerosing cholangitis and to determine the appropriate management of patients with confirmed or suspected cholangiocarcinoma. Between 1984 and 1997, 25 patients (18%) were diagnosed with cholangiocarcinoma among 139 patients with primary sclerosing cholangitis. The diagnosis of primary sclerosing cholangitis was made coincident with the diagnosis of cholangiocarcinoma in 12 patients and preceded it by a mean of 62 months in the remaining 13 patients. The incidence of inflammatory bowel disease was higher (P

Original languageEnglish (US)
Pages (from-to)357-368
Number of pages12
JournalJournal of Gastrointestinal Surgery
Volume3
Issue number4
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Cholangiocarcinoma
Carcinoembryonic Antigen
Inflammatory Bowel Diseases
Cause of Death
Carbohydrates
Antigens
Incidence

Keywords

  • Biliary tract malignancies
  • Cholangiocarcinoma
  • Liver transplantation
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Surgery

Cite this

Abrendt, S. A., Pitt, H. A., Nakeeb, A., Klein, A. S., Lillemoe, K. D., Kalloo, A. N., & Cameron, J. L. (1999). Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis. Journal of Gastrointestinal Surgery, 3(4), 357-368.

Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis. / Abrendt, Steven A.; Pitt, Henry A.; Nakeeb, Attila; Klein, Andrew S.; Lillemoe, Keith D.; Kalloo, Anthony N.; Cameron, John L.

In: Journal of Gastrointestinal Surgery, Vol. 3, No. 4, 07.1999, p. 357-368.

Research output: Contribution to journalArticle

Abrendt, SA, Pitt, HA, Nakeeb, A, Klein, AS, Lillemoe, KD, Kalloo, AN & Cameron, JL 1999, 'Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis', Journal of Gastrointestinal Surgery, vol. 3, no. 4, pp. 357-368.
Abrendt SA, Pitt HA, Nakeeb A, Klein AS, Lillemoe KD, Kalloo AN et al. Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis. Journal of Gastrointestinal Surgery. 1999 Jul;3(4):357-368.
Abrendt, Steven A. ; Pitt, Henry A. ; Nakeeb, Attila ; Klein, Andrew S. ; Lillemoe, Keith D. ; Kalloo, Anthony N. ; Cameron, John L. / Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis. In: Journal of Gastrointestinal Surgery. 1999 ; Vol. 3, No. 4. pp. 357-368.
@article{2c5126797fc3459eabce6643057ca883,
title = "Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis",
abstract = "Cholangiocarcinoma remains difficult to diagnose and is a major cause of death in patients with primary sclerosing cholangitis. Recently serum carcinoembryonic antigen and carbohydrate antigen 19-9 (CA 19-9) levels have been reported to improve diagnostic accuracy in patients with cholangiocarcinoma and primary sclerosing cholangitis. We reviewed our experience with cholangiocarcinoma complicating primary sclerosing cholangitis to identify clinical factors associated with cholangiocarcinoma in patients with primary sclerosing cholangitis and to determine the appropriate management of patients with confirmed or suspected cholangiocarcinoma. Between 1984 and 1997, 25 patients (18{\%}) were diagnosed with cholangiocarcinoma among 139 patients with primary sclerosing cholangitis. The diagnosis of primary sclerosing cholangitis was made coincident with the diagnosis of cholangiocarcinoma in 12 patients and preceded it by a mean of 62 months in the remaining 13 patients. The incidence of inflammatory bowel disease was higher (P",
keywords = "Biliary tract malignancies, Cholangiocarcinoma, Liver transplantation, Primary sclerosing cholangitis",
author = "Abrendt, {Steven A.} and Pitt, {Henry A.} and Attila Nakeeb and Klein, {Andrew S.} and Lillemoe, {Keith D.} and Kalloo, {Anthony N.} and Cameron, {John L.}",
year = "1999",
month = "7",
language = "English (US)",
volume = "3",
pages = "357--368",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Diagnosis and Management of Cholangiocarcinoma in Primary Sclerosing Cholangitis

AU - Abrendt, Steven A.

AU - Pitt, Henry A.

AU - Nakeeb, Attila

AU - Klein, Andrew S.

AU - Lillemoe, Keith D.

AU - Kalloo, Anthony N.

AU - Cameron, John L.

PY - 1999/7

Y1 - 1999/7

N2 - Cholangiocarcinoma remains difficult to diagnose and is a major cause of death in patients with primary sclerosing cholangitis. Recently serum carcinoembryonic antigen and carbohydrate antigen 19-9 (CA 19-9) levels have been reported to improve diagnostic accuracy in patients with cholangiocarcinoma and primary sclerosing cholangitis. We reviewed our experience with cholangiocarcinoma complicating primary sclerosing cholangitis to identify clinical factors associated with cholangiocarcinoma in patients with primary sclerosing cholangitis and to determine the appropriate management of patients with confirmed or suspected cholangiocarcinoma. Between 1984 and 1997, 25 patients (18%) were diagnosed with cholangiocarcinoma among 139 patients with primary sclerosing cholangitis. The diagnosis of primary sclerosing cholangitis was made coincident with the diagnosis of cholangiocarcinoma in 12 patients and preceded it by a mean of 62 months in the remaining 13 patients. The incidence of inflammatory bowel disease was higher (P

AB - Cholangiocarcinoma remains difficult to diagnose and is a major cause of death in patients with primary sclerosing cholangitis. Recently serum carcinoembryonic antigen and carbohydrate antigen 19-9 (CA 19-9) levels have been reported to improve diagnostic accuracy in patients with cholangiocarcinoma and primary sclerosing cholangitis. We reviewed our experience with cholangiocarcinoma complicating primary sclerosing cholangitis to identify clinical factors associated with cholangiocarcinoma in patients with primary sclerosing cholangitis and to determine the appropriate management of patients with confirmed or suspected cholangiocarcinoma. Between 1984 and 1997, 25 patients (18%) were diagnosed with cholangiocarcinoma among 139 patients with primary sclerosing cholangitis. The diagnosis of primary sclerosing cholangitis was made coincident with the diagnosis of cholangiocarcinoma in 12 patients and preceded it by a mean of 62 months in the remaining 13 patients. The incidence of inflammatory bowel disease was higher (P

KW - Biliary tract malignancies

KW - Cholangiocarcinoma

KW - Liver transplantation

KW - Primary sclerosing cholangitis

UR - http://www.scopus.com/inward/record.url?scp=0033155688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033155688&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 357

EP - 368

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 4

ER -