Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images

James Fletcher, K. E. Walter, K. F. Witztum, J. L. Daly, F. K. Herbig, H. S. Mueller, R. M. Donati

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The diagnostic sensitivity of visually interpreted and computer-analyzed 201Tl myocardial perfusion images was compared to that of exercise electrocardiograms in 8 angiographically normal subjects and 24 patients with significant coronary artery disease. Visual interpretation was not significantly better than exercise ECGs. An index of perfusion homogeneity, derived from computer analysis of the 201Tl images, was more sensitive than visual interpretation (79% vs. 58%) and much more sensitive (p<0.05) than the exercise ECG (79% vs. 46%). The best overall sensitivity (88%) and specificity (75%) were achieved by combining computer analysis with exercise electrocardiography. The computer also permits enhanced detection of subtle perfusion changes which may not seem significant to the eye.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalRadiology
Volume128
Issue number2
StatePublished - 1978
Externally publishedYes

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Coronary Artery Disease
Electrocardiography
Perfusion
Exercise
Sensitivity and Specificity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Fletcher, J., Walter, K. E., Witztum, K. F., Daly, J. L., Herbig, F. K., Mueller, H. S., & Donati, R. M. (1978). Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. Radiology, 128(2), 423-427.

Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. / Fletcher, James; Walter, K. E.; Witztum, K. F.; Daly, J. L.; Herbig, F. K.; Mueller, H. S.; Donati, R. M.

In: Radiology, Vol. 128, No. 2, 1978, p. 423-427.

Research output: Contribution to journalArticle

Fletcher, J, Walter, KE, Witztum, KF, Daly, JL, Herbig, FK, Mueller, HS & Donati, RM 1978, 'Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images', Radiology, vol. 128, no. 2, pp. 423-427.
Fletcher J, Walter KE, Witztum KF, Daly JL, Herbig FK, Mueller HS et al. Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. Radiology. 1978;128(2):423-427.
Fletcher, James ; Walter, K. E. ; Witztum, K. F. ; Daly, J. L. ; Herbig, F. K. ; Mueller, H. S. ; Donati, R. M. / Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. In: Radiology. 1978 ; Vol. 128, No. 2. pp. 423-427.
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