Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images

J. W. Fletcher, K. E. Walter, K. F. Witztum, J. L. Daly, F. K. Herbig, H. S. Mueller, R. M. Donati

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The diagnostic sensitivity of visually interpreted and computer-analyzed 201Tl myocardial perfusion images was compared to that of exercise electrocardiograms in 8 angiographically normal subjects and 24 patients with significant coronary artery disease. Visual interpretation was not significantly better than exercise ECGs. An index of perfusion homogeneity, derived from computer analysis of the 201Tl images, was more sensitive than visual interpretation (79% vs. 58%) and much more sensitive (p<0.05) than the exercise ECG (79% vs. 46%). The best overall sensitivity (88%) and specificity (75%) were achieved by combining computer analysis with exercise electrocardiography. The computer also permits enhanced detection of subtle perfusion changes which may not seem significant to the eye.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalUnknown Journal
Volume128
Issue number2
DOIs
StatePublished - Jan 1 1978

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Coronary Artery Disease
Electrocardiography
Perfusion
Exercise
Sensitivity and Specificity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Fletcher, J. W., Walter, K. E., Witztum, K. F., Daly, J. L., Herbig, F. K., Mueller, H. S., & Donati, R. M. (1978). Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. Unknown Journal, 128(2), 423-427. https://doi.org/10.1148/128.2.423

Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. / Fletcher, J. W.; Walter, K. E.; Witztum, K. F.; Daly, J. L.; Herbig, F. K.; Mueller, H. S.; Donati, R. M.

In: Unknown Journal, Vol. 128, No. 2, 01.01.1978, p. 423-427.

Research output: Contribution to journalArticle

Fletcher, JW, Walter, KE, Witztum, KF, Daly, JL, Herbig, FK, Mueller, HS & Donati, RM 1978, 'Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images', Unknown Journal, vol. 128, no. 2, pp. 423-427. https://doi.org/10.1148/128.2.423
Fletcher, J. W. ; Walter, K. E. ; Witztum, K. F. ; Daly, J. L. ; Herbig, F. K. ; Mueller, H. S. ; Donati, R. M. / Diagnosis of coronary artery disease with 201Tl. Computer analysis of myocardial perfusion images. In: Unknown Journal. 1978 ; Vol. 128, No. 2. pp. 423-427.
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