Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Morie A. Gertz, Merrill Benson, Peter J. Dyck, Martha Grogan, Terresa Coelho, Marcia Cruz, John L. Berk, Violaine Plante-Bordeneuve, Hartmut H J Schmidt, Giampaolo Merlini

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

Original languageEnglish (US)
Pages (from-to)2451-2466
Number of pages16
JournalJournal of the American College of Cardiology
Volume66
Issue number21
DOIs
StatePublished - Dec 1 2015

Fingerprint

Amyloidosis
Cardiomyopathies
Therapeutics
Amyloidosis, Hereditary, Transthyretin-Related

Keywords

  • familial amyloid cardiomyopathy
  • familial amyloid polyneuropathy
  • genetics
  • liver transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gertz, M. A., Benson, M., Dyck, P. J., Grogan, M., Coelho, T., Cruz, M., ... Merlini, G. (2015). Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. Journal of the American College of Cardiology, 66(21), 2451-2466. https://doi.org/10.1016/j.jacc.2015.09.075

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. / Gertz, Morie A.; Benson, Merrill; Dyck, Peter J.; Grogan, Martha; Coelho, Terresa; Cruz, Marcia; Berk, John L.; Plante-Bordeneuve, Violaine; Schmidt, Hartmut H J; Merlini, Giampaolo.

In: Journal of the American College of Cardiology, Vol. 66, No. 21, 01.12.2015, p. 2451-2466.

Research output: Contribution to journalArticle

Gertz, MA, Benson, M, Dyck, PJ, Grogan, M, Coelho, T, Cruz, M, Berk, JL, Plante-Bordeneuve, V, Schmidt, HHJ & Merlini, G 2015, 'Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis', Journal of the American College of Cardiology, vol. 66, no. 21, pp. 2451-2466. https://doi.org/10.1016/j.jacc.2015.09.075
Gertz, Morie A. ; Benson, Merrill ; Dyck, Peter J. ; Grogan, Martha ; Coelho, Terresa ; Cruz, Marcia ; Berk, John L. ; Plante-Bordeneuve, Violaine ; Schmidt, Hartmut H J ; Merlini, Giampaolo. / Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. In: Journal of the American College of Cardiology. 2015 ; Vol. 66, No. 21. pp. 2451-2466.
@article{3a812eaee6704b8caf1ef38432b1f7f8,
title = "Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis",
abstract = "Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.",
keywords = "familial amyloid cardiomyopathy, familial amyloid polyneuropathy, genetics, liver transplantation",
author = "Gertz, {Morie A.} and Merrill Benson and Dyck, {Peter J.} and Martha Grogan and Terresa Coelho and Marcia Cruz and Berk, {John L.} and Violaine Plante-Bordeneuve and Schmidt, {Hartmut H J} and Giampaolo Merlini",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.jacc.2015.09.075",
language = "English (US)",
volume = "66",
pages = "2451--2466",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "21",

}

TY - JOUR

T1 - Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

AU - Gertz, Morie A.

AU - Benson, Merrill

AU - Dyck, Peter J.

AU - Grogan, Martha

AU - Coelho, Terresa

AU - Cruz, Marcia

AU - Berk, John L.

AU - Plante-Bordeneuve, Violaine

AU - Schmidt, Hartmut H J

AU - Merlini, Giampaolo

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

AB - Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

KW - familial amyloid cardiomyopathy

KW - familial amyloid polyneuropathy

KW - genetics

KW - liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=84961062552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961062552&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2015.09.075

DO - 10.1016/j.jacc.2015.09.075

M3 - Article

C2 - 26610878

AN - SCOPUS:84961062552

VL - 66

SP - 2451

EP - 2466

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 21

ER -