Diagnostic approach to myelodysplastic syndromes

Shanxiang Zhang, Jiehao Zhou, Mehdi Nassiri, Magdalena Czader

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic stem cell neoplasms manifesting as cytopenia(s), morphologic dysplasia, functional abnormalities of hematopoietic lineages and a propensity to progress to acute myeloid leukemia. MDS is relatively common, particularly in the elderly population. In this chapter, we describe an integrated approach to a diagnosis of MDS. Relevant clinical history and specimens required for a complete diagnostic work-up are discussed. The key morphologic features including blasts and dysplasia seen in hematopoietic populations are described in detail. The contribution of flow cytometric immunophenotyping and cytogenetics/genetics to the routine diagnosis and the prediction of prognosis are discussed. Finally, the current 2008 WHO classification of MDS including the salient diagnostic features and major differential diagnoses are reviewed. Rare MDS types associated with unique morphology (MDS with fibrosis, hypoplastic MDS and erythroid-predominant MDS) are also presented.

Original languageEnglish (US)
Title of host publicationMyelodysplastic Syndromes
Subtitle of host publicationFrom Pathogenesis to Diagnosis and Therapy
PublisherNova Science Publishers, Inc.
Pages25-60
Number of pages36
ISBN (Print)9781624175749
StatePublished - Jan 1 2013

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zhang, S., Zhou, J., Nassiri, M., & Czader, M. (2013). Diagnostic approach to myelodysplastic syndromes. In Myelodysplastic Syndromes: From Pathogenesis to Diagnosis and Therapy (pp. 25-60). Nova Science Publishers, Inc..