Diagnostic Interview for Genetic Studies: Validity and reliability of the Croatian version

Ana Kralj, Milenka Dedić, Andela Kovačević, Mario Malički, Jelena Dedić, Marina Pelivan, Dubravka Vuković, Carrie Fisher, Rachel L. Kember, John Nurnberger, Maja Bućan, Dolores Britvić

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective To test the validity and reliability of the Diagnostic Interview for Genetic Studies (DIGS) in patients with mental illness in Croatia. Materials and methods Following translation, backtranslation, and pilot testing, the Croatian version of DIGS (CRO-DIGS) was administered to a total of 150 inpatients and outpatients diagnosed at the Clinical Hospital in Split with bipolar and major depressive disorder (n=56), schizophrenia and schizoaffective disorder (n=62), and alcohol dependence or use disorders (n=32). Initial testing was performed independently by one interviewer and one observer blinded to the diagnosis, and a retest was performed after 8 weeks by a third examiner. Results The validity of CRO-DIGS was high (κ=0.916), with an excellent inter-rater (κ=0.824) reliability, especially for bipolar disorder (κ=0.956). Following an 8 week testretest interval, the reliability for all diagnoses was found to be excellent (κ=0.843). Conclusion Our study has shown excellent validity and reliability of the Croatian version of DIGS, making it a promising instrument to assess mental illness of patients. The development of a valid and reliable diagnostic tool such as the CRO-DIGS will considerably advance the scientific communities ability to carry out genetic studies of psychiatric illness in the region. Psychiatr Genet 27:1722

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalPsychiatric genetics
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Croatia
  • Diagnostic Interview for Genetic Studies
  • Mental illness
  • Validation and reliability

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Kralj, A., Dedić, M., Kovačević, A., Malički, M., Dedić, J., Pelivan, M., Vuković, D., Fisher, C., Kember, R. L., Nurnberger, J., Bućan, M., & Britvić, D. (2017). Diagnostic Interview for Genetic Studies: Validity and reliability of the Croatian version. Psychiatric genetics, 27(1), 17-22. https://doi.org/10.1097/YPG.0000000000000154