Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version

Žana Kralj, Milenka Dedić, Anđela Kovačević, Mario Malički, Jelena Dedić, Marina Pelivan, Dubravka Vuković, Carrie Fisher, Rachel L. Kember, John Nurnberger, Maja Bućan, Dolores Britvić

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To test the validity and reliability of the Diagnostic Interview for Genetic Studies (DIGS) in patients with mental illness in Croatia. MATERIALS AND METHODS: Following translation, back-translation, and pilot testing, the Croatian version of DIGS (CRO-DIGS) was administered to a total of 150 inpatients and outpatients diagnosed at the Clinical Hospital in Split with bipolar and major depressive disorder (n=56), schizophrenia and schizoaffective disorder (n=62), and alcohol dependence or use disorders (n=32). Initial testing was performed independently by one interviewer and one observer blinded to the diagnosis, and a retest was performed after 8 weeks by a third examiner. RESULTS: The validity of CRO-DIGS was high (κ=0.916), with an excellent inter-rater (κ=0.824) reliability, especially for bipolar disorder (κ=0.956). Following an 8 week test–retest interval, the reliability for all diagnoses was found to be excellent (κ=0.843). CONCLUSION: Our study has shown excellent validity and reliability of the Croatian version of DIGS, making it a promising instrument to assess mental illness of patients. The development of a valid and reliable diagnostic tool such as the CRO-DIGS will considerably advance the scientific communities’ ability to carry out genetic studies of psychiatric illness in the region.

Original languageEnglish (US)
JournalPsychiatric Genetics
DOIs
StateAccepted/In press - Oct 21 2016

Fingerprint

Reproducibility of Results
Interviews
Mentally Ill Persons
Croatia
Aptitude
Major Depressive Disorder
Bipolar Disorder
Psychotic Disorders
Alcoholism
Psychiatry
Inpatients
Schizophrenia
Outpatients

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Kralj, Ž., Dedić, M., Kovačević, A., Malički, M., Dedić, J., Pelivan, M., ... Britvić, D. (Accepted/In press). Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version. Psychiatric Genetics. https://doi.org/10.1097/YPG.0000000000000154

Diagnostic Interview for Genetic Studies : validity and reliability of the Croatian version. / Kralj, Žana; Dedić, Milenka; Kovačević, Anđela; Malički, Mario; Dedić, Jelena; Pelivan, Marina; Vuković, Dubravka; Fisher, Carrie; Kember, Rachel L.; Nurnberger, John; Bućan, Maja; Britvić, Dolores.

In: Psychiatric Genetics, 21.10.2016.

Research output: Contribution to journalArticle

Kralj, Ž, Dedić, M, Kovačević, A, Malički, M, Dedić, J, Pelivan, M, Vuković, D, Fisher, C, Kember, RL, Nurnberger, J, Bućan, M & Britvić, D 2016, 'Diagnostic Interview for Genetic Studies: validity and reliability of the Croatian version', Psychiatric Genetics. https://doi.org/10.1097/YPG.0000000000000154
Kralj, Žana ; Dedić, Milenka ; Kovačević, Anđela ; Malički, Mario ; Dedić, Jelena ; Pelivan, Marina ; Vuković, Dubravka ; Fisher, Carrie ; Kember, Rachel L. ; Nurnberger, John ; Bućan, Maja ; Britvić, Dolores. / Diagnostic Interview for Genetic Studies : validity and reliability of the Croatian version. In: Psychiatric Genetics. 2016.
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AU - Dedić, Jelena

AU - Pelivan, Marina

AU - Vuković, Dubravka

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