Diagnostic methodology and technology in molecular genetic pathology

Josephine Wu, Feiy Ye, Miao Cui, Robert Shibata, Ruliang Xu, Liang Cheng, David Y. Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The technology for molecular diagnosis has significantly advanced during the past decade that has led to revolutionary changes in molecular testing. This chapter describes common methodologies used in molecular diagnosis including sample collection and preparation, DNA detection and amplification, DNA sequencing, and proteomic methods. For each method, the principle, application, advantages, and limitations were discussed. However, for specific clinical application, please refer to other chapters contained in this book.

Original languageEnglish (US)
Title of host publicationMolecular Genetic Pathology
Subtitle of host publicationSecond Edition
PublisherSpringer New York
Number of pages90
ISBN (Electronic)9781461448006
ISBN (Print)1461447992, 9781461447993
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Wu, J., Ye, F., Cui, M., Shibata, R., Xu, R., Cheng, L., & Zhang, D. Y. (2013). Diagnostic methodology and technology in molecular genetic pathology. In Molecular Genetic Pathology: Second Edition (Vol. 9781461448006, pp. 211-300). Springer New York. https://doi.org/10.1007/978-1-4614-4800-6-9