Dialysate aluminium concentration and renal bone disease

G. S. Walker, J. E. Aaron, M. Peacock, P. J. Robinson, A. M. Davison

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

We studied 40 patients maintained on regular hemodialysis, using radiology and quantitative bone histology to assess the relationship between renal and bone disease and exposure to aluminium. Fractures were significantly more common in patients exposed to high dialysate aluminium concentrations. The histologic indices of osteomalacia were significantly related to the prevailing dialysate aluminium concentration, in such a way that higher aluminium levels were associated with more osteomalacia. Patients who had been exposed to higher concentrations of aluminium also tended to have a lower plasma phosphate concentration, and associated hypercalcemia was seen in 6 patients with osteomalacia. These findings suggest that aluminium is a toxic agent associated with a mineralizing defect in the bone of renal failure patients. This may explain the incomplete response of some patients with renal osteomalacia to administration of 1,25-dihydroxy vitamin D.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalUnknown Journal
Volume21
Issue number2
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Nephrology

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    Walker, G. S., Aaron, J. E., Peacock, M., Robinson, P. J., & Davison, A. M. (1982). Dialysate aluminium concentration and renal bone disease. Unknown Journal, 21(2), 411-415. https://doi.org/10.1038/ki.1982.37