Dietary and nutritional factors and pancreatic cancer

A case-control study based on direct interviews

Debra T. Silverman, Christine A. Swanson, Gloria Gridley, Sholom Wacholder, Raymond S. Greenberg, Linda M. Brown, Richard B. Hayes, G. Marie Swanson, Janet B. Schoenberg, Linda M. Pottern, Ann G. Schwartz, Joseph F. Fraumeni, Robert N. Hoover

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Background: The relationship between diet and pancreatic cancer remains unclear. In this study, we assessed the role of diet and nutrition as risk factors for pancreatic cancer, using data obtained from direct interviews only, rather than data from less reliable interviews with next of kin. We evaluated whether dietary factors could explain the higher incidence of pancreatic cancer experienced by black Americans compared with white Americans. Methods: We conducted a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and 10 New Jersey counties from August 1986 through April 1989. Reliable dietary histories were obtained for 436 patients and 2003 general-population control subjects aged 30-79 years. Results: Obesity was associated with a statistically significant 50%-60% increased risk of pancreatic cancer that was consistent by sex and race. Although the magnitude of risk associated with obesity was identical in blacks and whites, a higher percentage of blacks were obese than were whites (women: 38% versus 16%; men: 27% versus 22%). A statistically significant positive trend in risk was observed with increasing caloric intake, with subjects in the highest quartile of caloric intake experiencing a 70% higher risk than those in the lowest quartile. A statistically significant interaction between body mass index (weight in kg/height in m2 for men and weight in kg/height in m1.5 for women) and total caloric intake was observed that was consistent by sex and race. Subjects in the highest quartile of both body mass index and caloric intake had a statistically significant 180% higher risk than those in the lowest quartile. Conclusions: Obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk of this disease among blacks than among whites in the United States, particularly among women. Furthermore, the interaction between body mass index and caloric intake suggests the importance of energy balance in pancreatic carcinogenesis.

Original languageEnglish (US)
Pages (from-to)1710-1719
Number of pages10
JournalJournal of the National Cancer Institute
Volume90
Issue number22
StatePublished - Nov 18 1998
Externally publishedYes

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Pancreatic Neoplasms
Case-Control Studies
Energy Intake
Interviews
Body Mass Index
Obesity
Diet
Weights and Measures
Population Control
Carcinogenesis
Incidence
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Silverman, D. T., Swanson, C. A., Gridley, G., Wacholder, S., Greenberg, R. S., Brown, L. M., ... Hoover, R. N. (1998). Dietary and nutritional factors and pancreatic cancer: A case-control study based on direct interviews. Journal of the National Cancer Institute, 90(22), 1710-1719.

Dietary and nutritional factors and pancreatic cancer : A case-control study based on direct interviews. / Silverman, Debra T.; Swanson, Christine A.; Gridley, Gloria; Wacholder, Sholom; Greenberg, Raymond S.; Brown, Linda M.; Hayes, Richard B.; Swanson, G. Marie; Schoenberg, Janet B.; Pottern, Linda M.; Schwartz, Ann G.; Fraumeni, Joseph F.; Hoover, Robert N.

In: Journal of the National Cancer Institute, Vol. 90, No. 22, 18.11.1998, p. 1710-1719.

Research output: Contribution to journalArticle

Silverman, DT, Swanson, CA, Gridley, G, Wacholder, S, Greenberg, RS, Brown, LM, Hayes, RB, Swanson, GM, Schoenberg, JB, Pottern, LM, Schwartz, AG, Fraumeni, JF & Hoover, RN 1998, 'Dietary and nutritional factors and pancreatic cancer: A case-control study based on direct interviews', Journal of the National Cancer Institute, vol. 90, no. 22, pp. 1710-1719.
Silverman DT, Swanson CA, Gridley G, Wacholder S, Greenberg RS, Brown LM et al. Dietary and nutritional factors and pancreatic cancer: A case-control study based on direct interviews. Journal of the National Cancer Institute. 1998 Nov 18;90(22):1710-1719.
Silverman, Debra T. ; Swanson, Christine A. ; Gridley, Gloria ; Wacholder, Sholom ; Greenberg, Raymond S. ; Brown, Linda M. ; Hayes, Richard B. ; Swanson, G. Marie ; Schoenberg, Janet B. ; Pottern, Linda M. ; Schwartz, Ann G. ; Fraumeni, Joseph F. ; Hoover, Robert N. / Dietary and nutritional factors and pancreatic cancer : A case-control study based on direct interviews. In: Journal of the National Cancer Institute. 1998 ; Vol. 90, No. 22. pp. 1710-1719.
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abstract = "Background: The relationship between diet and pancreatic cancer remains unclear. In this study, we assessed the role of diet and nutrition as risk factors for pancreatic cancer, using data obtained from direct interviews only, rather than data from less reliable interviews with next of kin. We evaluated whether dietary factors could explain the higher incidence of pancreatic cancer experienced by black Americans compared with white Americans. Methods: We conducted a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and 10 New Jersey counties from August 1986 through April 1989. Reliable dietary histories were obtained for 436 patients and 2003 general-population control subjects aged 30-79 years. Results: Obesity was associated with a statistically significant 50{\%}-60{\%} increased risk of pancreatic cancer that was consistent by sex and race. Although the magnitude of risk associated with obesity was identical in blacks and whites, a higher percentage of blacks were obese than were whites (women: 38{\%} versus 16{\%}; men: 27{\%} versus 22{\%}). A statistically significant positive trend in risk was observed with increasing caloric intake, with subjects in the highest quartile of caloric intake experiencing a 70{\%} higher risk than those in the lowest quartile. A statistically significant interaction between body mass index (weight in kg/height in m2 for men and weight in kg/height in m1.5 for women) and total caloric intake was observed that was consistent by sex and race. Subjects in the highest quartile of both body mass index and caloric intake had a statistically significant 180{\%} higher risk than those in the lowest quartile. Conclusions: Obesity is a risk factor for pancreatic cancer and appears to contribute to the higher risk of this disease among blacks than among whites in the United States, particularly among women. Furthermore, the interaction between body mass index and caloric intake suggests the importance of energy balance in pancreatic carcinogenesis.",
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AU - Hayes, Richard B.

AU - Swanson, G. Marie

AU - Schoenberg, Janet B.

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AU - Schwartz, Ann G.

AU - Fraumeni, Joseph F.

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