Dietary phosphate deprivation in women and men: Effects on mineral and acid balances, parathyroid hormone and the metabolism of 25-oh-vitamin d

Jesus H. Dominguez, Richard W. Gray, Jacob Lemann

Research output: Contribution to journalArticle

97 Scopus citations


We evaluated the effects of dietary PO4 restriction on 25-OH-Vitamin D3 metabolism, serum iPTH levels, and mineral balances in healthy women and men. PO4 balances were progressively negative because of fecal losses without sex difference. Turnover of the plasma 25-OH-D pool was increased from 5.8 ± 0.4 to 12 ± 1.2 nmol/day; P < 0.001, despite a fall in serum iPTH of -1.1 ± 0.3 µlEq/ml; P < 0.01. In both sexes, net intestinal calcium and magnesium absorption increased in proportion to a more rapid turnover of the plasma 25-OH-D pool, implying increased renal 1, 25-(OH)2- D3 production. By contrast, there was a striking sex difference in the response of serum PCX, to dietary PO4deprivation; the levels falling progressively in women, but remaining at control levels in men. Women demonstrated progressive hypercalciuria and negative Ca balances while in men the increments in intestinal Ca absorption were approximately matched by the increments in urinary Ca excretion so that Ca balances were not different from zero.

Original languageEnglish (US)
Pages (from-to)1056-1068
Number of pages13
JournalJournal of Clinical Endocrinology and Metabolism
Issue number5
StatePublished - Nov 1976


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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