Dietary phosphate deprivation in women and men

effects on mineral and acid balances, parathyroid hormone and the metabolism of 25 OH vitamin D

Jesus Dominguez, R. W. Gray, J. Lemann

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The authors evaluated the effects of dietary PO4 restriction on 25 OH Vitamin D3 metabolism, serum iPTH levels, and mineral balances in healthy women and men. PO4 balances were progressively negative because of fecal losses without sex difference. Turnover of the plasma 25 OH D pool was increased from 5.8 ± 0.4 to 12 ± 1.2 nmol/day; P <0.001, despite a fall in serum iPTH of -1.1 ± 0.3 μlEq/ml; P <0.01. In both sexes, net intestinal calcium and magnesium absorption increased in proportion to a more rapid turnover of the plasma 25 OH D pool, implying increased renal 1,25 (OH)2 D3 production. By contrast, there was a striking sex difference in the response of serum PO4 to dietary PO4 deprivation; the levels falling progressively in women, but remaining at control levels in men. Women demonstrated progressive hypercalciuria and negative Ca balances while in men the increments in intestinal Ca absorption were approximately matched by the increments in urinary Ca excretion so that Ca balances were not different from zero.

Original languageEnglish (US)
Pages (from-to)1056-1068
Number of pages13
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number5
StatePublished - 1976
Externally publishedYes

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Parathyroid Hormone
Metabolism
Vitamin D
Minerals
Phosphates
Plasmas
Sex Characteristics
Acids
Cholecalciferol
Level control
Accidental Falls
Serum
Magnesium
Hypercalciuria
Intestinal Absorption
Calcium
Kidney

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

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abstract = "The authors evaluated the effects of dietary PO4 restriction on 25 OH Vitamin D3 metabolism, serum iPTH levels, and mineral balances in healthy women and men. PO4 balances were progressively negative because of fecal losses without sex difference. Turnover of the plasma 25 OH D pool was increased from 5.8 ± 0.4 to 12 ± 1.2 nmol/day; P <0.001, despite a fall in serum iPTH of -1.1 ± 0.3 μlEq/ml; P <0.01. In both sexes, net intestinal calcium and magnesium absorption increased in proportion to a more rapid turnover of the plasma 25 OH D pool, implying increased renal 1,25 (OH)2 D3 production. By contrast, there was a striking sex difference in the response of serum PO4 to dietary PO4 deprivation; the levels falling progressively in women, but remaining at control levels in men. Women demonstrated progressive hypercalciuria and negative Ca balances while in men the increments in intestinal Ca absorption were approximately matched by the increments in urinary Ca excretion so that Ca balances were not different from zero.",
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N2 - The authors evaluated the effects of dietary PO4 restriction on 25 OH Vitamin D3 metabolism, serum iPTH levels, and mineral balances in healthy women and men. PO4 balances were progressively negative because of fecal losses without sex difference. Turnover of the plasma 25 OH D pool was increased from 5.8 ± 0.4 to 12 ± 1.2 nmol/day; P <0.001, despite a fall in serum iPTH of -1.1 ± 0.3 μlEq/ml; P <0.01. In both sexes, net intestinal calcium and magnesium absorption increased in proportion to a more rapid turnover of the plasma 25 OH D pool, implying increased renal 1,25 (OH)2 D3 production. By contrast, there was a striking sex difference in the response of serum PO4 to dietary PO4 deprivation; the levels falling progressively in women, but remaining at control levels in men. Women demonstrated progressive hypercalciuria and negative Ca balances while in men the increments in intestinal Ca absorption were approximately matched by the increments in urinary Ca excretion so that Ca balances were not different from zero.

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