Dietary restrictions and drug interactions with monoamine oxidase inhibitors: An update

David A. Flockhart

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Monoamine oxidase inhibitors (MAOIs) are effective treatments for depression that has atypical features or that has failed to respond to other antidepressants. However, MAOIs are underused because clinicians are concerned about dietary and drug interactions with this class of medication. Hypertensive crisis and serotonin syndrome can occur in rare cases due to interactions between MAOIs and foods containing tyramine as well as interactions with serotonergic and sympathomimetic agents. A better understanding of the foods and drugs that can cause adverse reactions, as well as knowledge of newer MAOIs with mechanisms of action and delivery methods that reduce these risks, may help clinicians to consider the use of these medications, when appropriate, in their patients with depression.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of Clinical Psychiatry
Volume73
Issue numberSUPPL. 1
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Psychiatry and Mental health

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