Dietary restrictions and drug interactions with monoamine oxidase inhibitors

An update

David A. Flockhart

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Monoamine oxidase inhibitors (MAOIs) are effective treatments for depression that has atypical features or that has failed to respond to other antidepressants. However, MAOIs are underused because clinicians are concerned about dietary and drug interactions with this class of medication. Hypertensive crisis and serotonin syndrome can occur in rare cases due to interactions between MAOIs and foods containing tyramine as well as interactions with serotonergic and sympathomimetic agents. A better understanding of the foods and drugs that can cause adverse reactions, as well as knowledge of newer MAOIs with mechanisms of action and delivery methods that reduce these risks, may help clinicians to consider the use of these medications, when appropriate, in their patients with depression.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Clinical Psychiatry
Volume73
Issue numberSUPPL. 1
DOIs
StatePublished - 2012

Fingerprint

Monoamine Oxidase Inhibitors
Drug Interactions
Serotonin Syndrome
Serotonin Agents
Food
Sympathomimetics
Tyramine
Antidepressive Agents
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Dietary restrictions and drug interactions with monoamine oxidase inhibitors : An update. / Flockhart, David A.

In: Journal of Clinical Psychiatry, Vol. 73, No. SUPPL. 1, 2012, p. 17-24.

Research output: Contribution to journalArticle

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