Diferential bone and muscle recovery following hindlimb unloading in skeletally mature male rats

Matthew Allen, H. A. Hogan, S. A. Bloomfield

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally mature male rats in order to quantify the degree and timing of the expected mismatch between bone and muscle properties. Outcome variables were in vivo plantarflexor peak isometric torque and proximal tibial volumetric bone mineral density (vBMD). Proximal tibia vBMD was significantly lower than age-matched controls (-7.8%) after 28 days of HU, continued to decrease through day 28 of recovery (-10%) and did not recover until day 84 of recovery. Plantarflexor peak isometric torque was significantly reduced after 28 days of HU (-13.9%). Further reductions of isometric torque occurred after 7 days of recovery (-15%), but returned to age-matched control levels by day 14. The functional relationship between bone and muscle (vBMD/isometric torque) tended to increase after 28 days of HU (+7.8%), remained elevated after 7 days of reloading (+9.1%) and was significantly lower than age-matched controls on day 28 (-13.6%). This relatively rapid return of muscle strength, coupled with continued depression of bone density at the proximal tibia metaphysis, may increase the risk for skeletal injury during recovery from prolonged periods of reduced mechanical loading.

Original languageEnglish
Pages (from-to)217-225
Number of pages9
JournalJournal of Musculoskeletal Neuronal Interactions
Volume6
Issue number3
StatePublished - Jul 2006

Fingerprint

Hindlimb Suspension
Torque
Bone Density
Bone and Bones
Muscles
Tibia
Muscle Strength
Wounds and Injuries

Keywords

  • Bone density
  • Disuse
  • Muscle strength
  • Peripheral Quantitative Computed Tomography (pQCT)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Endocrinology

Cite this

Diferential bone and muscle recovery following hindlimb unloading in skeletally mature male rats. / Allen, Matthew; Hogan, H. A.; Bloomfield, S. A.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 6, No. 3, 07.2006, p. 217-225.

Research output: Contribution to journalArticle

@article{878f9c9086e4466a875aa313a0fcb6fb,
title = "Diferential bone and muscle recovery following hindlimb unloading in skeletally mature male rats",
abstract = "This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally mature male rats in order to quantify the degree and timing of the expected mismatch between bone and muscle properties. Outcome variables were in vivo plantarflexor peak isometric torque and proximal tibial volumetric bone mineral density (vBMD). Proximal tibia vBMD was significantly lower than age-matched controls (-7.8{\%}) after 28 days of HU, continued to decrease through day 28 of recovery (-10{\%}) and did not recover until day 84 of recovery. Plantarflexor peak isometric torque was significantly reduced after 28 days of HU (-13.9{\%}). Further reductions of isometric torque occurred after 7 days of recovery (-15{\%}), but returned to age-matched control levels by day 14. The functional relationship between bone and muscle (vBMD/isometric torque) tended to increase after 28 days of HU (+7.8{\%}), remained elevated after 7 days of reloading (+9.1{\%}) and was significantly lower than age-matched controls on day 28 (-13.6{\%}). This relatively rapid return of muscle strength, coupled with continued depression of bone density at the proximal tibia metaphysis, may increase the risk for skeletal injury during recovery from prolonged periods of reduced mechanical loading.",
keywords = "Bone density, Disuse, Muscle strength, Peripheral Quantitative Computed Tomography (pQCT)",
author = "Matthew Allen and Hogan, {H. A.} and Bloomfield, {S. A.}",
year = "2006",
month = "7",
language = "English",
volume = "6",
pages = "217--225",
journal = "Journal of Musculoskeletal Neuronal Interactions",
issn = "1108-7161",
publisher = "International Society of Musculoskeletal and Neuronal Interactions",
number = "3",

}

TY - JOUR

T1 - Diferential bone and muscle recovery following hindlimb unloading in skeletally mature male rats

AU - Allen, Matthew

AU - Hogan, H. A.

AU - Bloomfield, S. A.

PY - 2006/7

Y1 - 2006/7

N2 - This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally mature male rats in order to quantify the degree and timing of the expected mismatch between bone and muscle properties. Outcome variables were in vivo plantarflexor peak isometric torque and proximal tibial volumetric bone mineral density (vBMD). Proximal tibia vBMD was significantly lower than age-matched controls (-7.8%) after 28 days of HU, continued to decrease through day 28 of recovery (-10%) and did not recover until day 84 of recovery. Plantarflexor peak isometric torque was significantly reduced after 28 days of HU (-13.9%). Further reductions of isometric torque occurred after 7 days of recovery (-15%), but returned to age-matched control levels by day 14. The functional relationship between bone and muscle (vBMD/isometric torque) tended to increase after 28 days of HU (+7.8%), remained elevated after 7 days of reloading (+9.1%) and was significantly lower than age-matched controls on day 28 (-13.6%). This relatively rapid return of muscle strength, coupled with continued depression of bone density at the proximal tibia metaphysis, may increase the risk for skeletal injury during recovery from prolonged periods of reduced mechanical loading.

AB - This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally mature male rats in order to quantify the degree and timing of the expected mismatch between bone and muscle properties. Outcome variables were in vivo plantarflexor peak isometric torque and proximal tibial volumetric bone mineral density (vBMD). Proximal tibia vBMD was significantly lower than age-matched controls (-7.8%) after 28 days of HU, continued to decrease through day 28 of recovery (-10%) and did not recover until day 84 of recovery. Plantarflexor peak isometric torque was significantly reduced after 28 days of HU (-13.9%). Further reductions of isometric torque occurred after 7 days of recovery (-15%), but returned to age-matched control levels by day 14. The functional relationship between bone and muscle (vBMD/isometric torque) tended to increase after 28 days of HU (+7.8%), remained elevated after 7 days of reloading (+9.1%) and was significantly lower than age-matched controls on day 28 (-13.6%). This relatively rapid return of muscle strength, coupled with continued depression of bone density at the proximal tibia metaphysis, may increase the risk for skeletal injury during recovery from prolonged periods of reduced mechanical loading.

KW - Bone density

KW - Disuse

KW - Muscle strength

KW - Peripheral Quantitative Computed Tomography (pQCT)

UR - http://www.scopus.com/inward/record.url?scp=33750428902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750428902&partnerID=8YFLogxK

M3 - Article

C2 - 17142941

AN - SCOPUS:33750428902

VL - 6

SP - 217

EP - 225

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

SN - 1108-7161

IS - 3

ER -