Difference in regional neural fluctuations and functional connectivity in Crohn’s disease

a resting-state functional MRI study

Chunhui Bao, Peng Liu, Huirong Liu, Xiaoming Jin, Yin Shi, Luyi Wu, Xiaoqing Zeng, Jianye Zhang, Di Wang, Vince D. Calhoun, Jie Tian, Huangan Wu

Research output: Contribution to journalArticle

Abstract

Patients with Crohn’s disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were used to assess differences in spontaneous regional brain activity and functional connectivity. Compared to the HCs, patients with CD showed significantly higher ALFF values in hippocampus and parahippocampus (HIPP/paraHIPP), anterior cingulate cortex, insula, superior frontal cortex and precuneus. The ALFF values were significantly lower in secondary somatosensory cortex (S2), precentral gyrus, and medial prefrontal cortex. Functional connectivities between left HIPP and left inferior temporal cortex, and right middle cingulate cortex, HIPP, and fusiform area were significantly lower. The functional connectivities between right HIPP and right inferior orbitofrontal cortex and left HIPP were also significantly lower. Patients with CD showed higher or lower spontaneous activity in multiple brain regions. Altered activities in these brain regions may collectively reflect abnormal function and regulation of visceral pain and sensation, external environmental monitoring, and cognitive processing in these patients. Lower functional connectivity of the hippocampus-limbic system was observed in these patients. These findings may provide more information to elucidate the neurobiological mechanisms of the disease.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Feb 20 2018

Fingerprint

Crohn Disease
Magnetic Resonance Imaging
Brain
Gyrus Cinguli
Frontal Lobe
Prefrontal Cortex
Hippocampus
Visceral Pain
Limbic System
Parietal Lobe
Somatosensory Cortex
Environmental Monitoring
Temporal Lobe
Seeds

Keywords

  • Amplitude of low-frequency fluctuation
  • Crohn’s disease
  • Functional connectivity
  • Resting-state functional MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Difference in regional neural fluctuations and functional connectivity in Crohn’s disease : a resting-state functional MRI study. / Bao, Chunhui; Liu, Peng; Liu, Huirong; Jin, Xiaoming; Shi, Yin; Wu, Luyi; Zeng, Xiaoqing; Zhang, Jianye; Wang, Di; Calhoun, Vince D.; Tian, Jie; Wu, Huangan.

In: Brain Imaging and Behavior, 20.02.2018, p. 1-9.

Research output: Contribution to journalArticle

Bao, Chunhui ; Liu, Peng ; Liu, Huirong ; Jin, Xiaoming ; Shi, Yin ; Wu, Luyi ; Zeng, Xiaoqing ; Zhang, Jianye ; Wang, Di ; Calhoun, Vince D. ; Tian, Jie ; Wu, Huangan. / Difference in regional neural fluctuations and functional connectivity in Crohn’s disease : a resting-state functional MRI study. In: Brain Imaging and Behavior. 2018 ; pp. 1-9.
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