Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin

J. C. Sackellares, G. J. Siegel, B. W. Abou-Khalil, T. W. Hood, S. Gilman, P. E. McKeever, R. D. Hichwa, Gary Hutchins

Research output: Contribution to journalArticle

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Abstract

We performed interictal [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in 17 patients with well-defined unilateral anterior mesial temporal epileptogenic foci as determined by EEG procedures. Sixteen of these patients subsequently underwent surgical resection of the epileptogenic focus. We measured local cerebral metabolic rates for glucose in mesial and lateral temporal structures and compared them with metabolic rates for analogous regions in 16 healthy normal volunteers and the contralateral hemisphere of the epileptic patients. We found relative hypometabolism ipsilateral to the seizure focus more frequently and to a greater degree in the lateral than in the mesial temporal cortex. Since the physiologic abnormalities involved mesial temporal structures, this observation suggests that functional pathways exist between mesial and lateral temporal cortex normally and that these pathways are altered in epilepsy of mesial temporal origin. Hypometabolism did not correlate well with histologic abnormalities in the surgical specimens.

Original languageEnglish (US)
Pages (from-to)1420-1426
Number of pages7
JournalNeurology
Volume40
Issue number9
StatePublished - Sep 1990
Externally publishedYes

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Epilepsy
Temporal Lobe
Healthy Volunteers
Fluorodeoxyglucose F18
Positron-Emission Tomography
Electroencephalography
Seizures
Glucose

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sackellares, J. C., Siegel, G. J., Abou-Khalil, B. W., Hood, T. W., Gilman, S., McKeever, P. E., ... Hutchins, G. (1990). Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. Neurology, 40(9), 1420-1426.

Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. / Sackellares, J. C.; Siegel, G. J.; Abou-Khalil, B. W.; Hood, T. W.; Gilman, S.; McKeever, P. E.; Hichwa, R. D.; Hutchins, Gary.

In: Neurology, Vol. 40, No. 9, 09.1990, p. 1420-1426.

Research output: Contribution to journalArticle

Sackellares, JC, Siegel, GJ, Abou-Khalil, BW, Hood, TW, Gilman, S, McKeever, PE, Hichwa, RD & Hutchins, G 1990, 'Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin', Neurology, vol. 40, no. 9, pp. 1420-1426.
Sackellares JC, Siegel GJ, Abou-Khalil BW, Hood TW, Gilman S, McKeever PE et al. Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. Neurology. 1990 Sep;40(9):1420-1426.
Sackellares, J. C. ; Siegel, G. J. ; Abou-Khalil, B. W. ; Hood, T. W. ; Gilman, S. ; McKeever, P. E. ; Hichwa, R. D. ; Hutchins, Gary. / Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin. In: Neurology. 1990 ; Vol. 40, No. 9. pp. 1420-1426.
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