Abstract
Background: Striatal dopamine (DA) has been implicated in alcohol use disorders, but it is still unclear whether or not alcohol can induce dopamine release in social drinkers. Furthermore, no data exist on dopamine responses to alcohol in dependent drinkers. We sought to characterize the DA responses to alcohol intoxication in moderately large samples of social drinkers (SD) and nontreatment-seeking alcoholics (NTS). Methods: Twenty-four SD and twenty-one NTS received two [11C]raclopride (RAC) PET scans; one at rest, and one during an intravenous alcohol infusion, with a prescribed ascent to a target breath alcohol concentration (BrAC), at which it was then "clamped." The alcohol clamp was started 5 min after scan start, with a linear increase in BrAC over 15 min to the target of 80 mg%, the legal threshold for intoxication. Target BrAC was maintained for 30 min. Voxel-wise binding potential (BPND) was estimated with MRTM2. Results: IV EtOH induced significant increases in DA in the right ventral striatum in NTS, but not SD. No decreases in DA were observed in either group. Conclusions: Alcohol intoxication results in distinct anatomic profiles of DA responses in SD and NTS, suggesting that in NTS, the striatal DA system may process effects of alcohol intoxication differently than in SD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-169 |
| Number of pages | 7 |
| Journal | Drug and Alcohol Dependence |
| Volume | 160 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Alcohol
- Dopamine
- Positron emission tomography
- Raclopride
- Ventral striatum
ASJC Scopus subject areas
- Psychiatry and Mental health
- Toxicology
- Pharmacology
- Pharmacology (medical)
Cite this
Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. / Yoder, Karmen; Albrecht, Daniel S.; Dzemidzic, Mario; Normandin, Marc D.; Federici, Lauren M.; Graves, Tammy; Herring, Christine M.; Hile, Karen L.; Walters, James W.; Liang, Tiebing; Plawecki, Martin H.; O'Connor, Sean; Kareken, David.
In: Drug and Alcohol Dependence, Vol. 160, 01.03.2016, p. 163-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics
AU - Yoder, Karmen
AU - Albrecht, Daniel S.
AU - Dzemidzic, Mario
AU - Normandin, Marc D.
AU - Federici, Lauren M.
AU - Graves, Tammy
AU - Herring, Christine M.
AU - Hile, Karen L.
AU - Walters, James W.
AU - Liang, Tiebing
AU - Plawecki, Martin H.
AU - O'Connor, Sean
AU - Kareken, David
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background: Striatal dopamine (DA) has been implicated in alcohol use disorders, but it is still unclear whether or not alcohol can induce dopamine release in social drinkers. Furthermore, no data exist on dopamine responses to alcohol in dependent drinkers. We sought to characterize the DA responses to alcohol intoxication in moderately large samples of social drinkers (SD) and nontreatment-seeking alcoholics (NTS). Methods: Twenty-four SD and twenty-one NTS received two [11C]raclopride (RAC) PET scans; one at rest, and one during an intravenous alcohol infusion, with a prescribed ascent to a target breath alcohol concentration (BrAC), at which it was then "clamped." The alcohol clamp was started 5 min after scan start, with a linear increase in BrAC over 15 min to the target of 80 mg%, the legal threshold for intoxication. Target BrAC was maintained for 30 min. Voxel-wise binding potential (BPND) was estimated with MRTM2. Results: IV EtOH induced significant increases in DA in the right ventral striatum in NTS, but not SD. No decreases in DA were observed in either group. Conclusions: Alcohol intoxication results in distinct anatomic profiles of DA responses in SD and NTS, suggesting that in NTS, the striatal DA system may process effects of alcohol intoxication differently than in SD.
AB - Background: Striatal dopamine (DA) has been implicated in alcohol use disorders, but it is still unclear whether or not alcohol can induce dopamine release in social drinkers. Furthermore, no data exist on dopamine responses to alcohol in dependent drinkers. We sought to characterize the DA responses to alcohol intoxication in moderately large samples of social drinkers (SD) and nontreatment-seeking alcoholics (NTS). Methods: Twenty-four SD and twenty-one NTS received two [11C]raclopride (RAC) PET scans; one at rest, and one during an intravenous alcohol infusion, with a prescribed ascent to a target breath alcohol concentration (BrAC), at which it was then "clamped." The alcohol clamp was started 5 min after scan start, with a linear increase in BrAC over 15 min to the target of 80 mg%, the legal threshold for intoxication. Target BrAC was maintained for 30 min. Voxel-wise binding potential (BPND) was estimated with MRTM2. Results: IV EtOH induced significant increases in DA in the right ventral striatum in NTS, but not SD. No decreases in DA were observed in either group. Conclusions: Alcohol intoxication results in distinct anatomic profiles of DA responses in SD and NTS, suggesting that in NTS, the striatal DA system may process effects of alcohol intoxication differently than in SD.
KW - Alcohol
KW - Dopamine
KW - Positron emission tomography
KW - Raclopride
KW - Ventral striatum
UR - http://www.scopus.com/inward/record.url?scp=84959870756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959870756&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2016.01.001
DO - 10.1016/j.drugalcdep.2016.01.001
M3 - Article
VL - 160
SP - 163
EP - 169
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
ER -