Differences in ocular blood flow between people of African and European descent with healthy eyes

Betül Kaskan, Koosha Ramezani, Alon Harris, Brent Siesky, Carine Olinde, Darrell WuDunn, Jennifer Eikenberry, Leslie A. Tobe, Lyne Racette

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To investigate differences in ocular blood flow between people of African descent (AD) and European descent (ED) with healthy eyes. Materials and Methods: Retrobulbar and retinal capillary blood flow was assessed in 1 eye of 58 participants (24 AD, 34 ED) with healthy eyes with systemic blood pressure lower than 140/90. Retrobulbar blood flow was measured in the ophthalmic artery (OA), central retinal artery (CRA), nasal posterior ciliary artery (NPCA) and temporal posterior ciliary artery (TPCA). Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) were assessed. Retinal capillary blood flow was assessed using mean retinal flow and avascular space defined as the percent of area measured with no blood flow. Groups were compared using t tests and Pearson correlations were compared using Fisher r-to-z transformation. Results: Compared with people of ED, people of AD had significantly lower EDV in the NPCA (P=0.01), and higher RI in the CRA (P=0.04) and TPCA (P=0.01). No significant differences were observed in mean retinal capillary flow or avascular area. In the CRA, a significant negative correlation was observed between pattern standard deviation and peak systolic velocity (P=0.02) in the AD group and this correlation was significantly different from that observed in the ED group (P=0.01). A significant correlation was also observed between pattern standard deviation and EDV (0.04) in the AD group. Conclusions: This study suggests that retrobulbar blood flow is lower in healthy eyes in persons of AD compared with ED. This may provide a mechanism through which people of AD are at increased risk for ophthalmic diseases such as glaucoma.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalJournal of Glaucoma
Volume25
Issue number9
DOIs
StatePublished - 2016

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Ciliary Arteries
Retinal Artery
Nose
Ophthalmic Artery
Eye Diseases
Glaucoma
Blood Pressure

Keywords

  • Glaucoma
  • Ocular blood flow
  • Racial difference
  • Visual function

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Differences in ocular blood flow between people of African and European descent with healthy eyes. / Kaskan, Betül; Ramezani, Koosha; Harris, Alon; Siesky, Brent; Olinde, Carine; WuDunn, Darrell; Eikenberry, Jennifer; Tobe, Leslie A.; Racette, Lyne.

In: Journal of Glaucoma, Vol. 25, No. 9, 2016, p. 709-715.

Research output: Contribution to journalArticle

Kaskan, B, Ramezani, K, Harris, A, Siesky, B, Olinde, C, WuDunn, D, Eikenberry, J, Tobe, LA & Racette, L 2016, 'Differences in ocular blood flow between people of African and European descent with healthy eyes', Journal of Glaucoma, vol. 25, no. 9, pp. 709-715. https://doi.org/10.1097/IJG.0000000000000509
Kaskan, Betül ; Ramezani, Koosha ; Harris, Alon ; Siesky, Brent ; Olinde, Carine ; WuDunn, Darrell ; Eikenberry, Jennifer ; Tobe, Leslie A. ; Racette, Lyne. / Differences in ocular blood flow between people of African and European descent with healthy eyes. In: Journal of Glaucoma. 2016 ; Vol. 25, No. 9. pp. 709-715.
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AU - Kaskan, Betül

AU - Ramezani, Koosha

AU - Harris, Alon

AU - Siesky, Brent

AU - Olinde, Carine

AU - WuDunn, Darrell

AU - Eikenberry, Jennifer

AU - Tobe, Leslie A.

AU - Racette, Lyne

PY - 2016

Y1 - 2016

N2 - Purpose: To investigate differences in ocular blood flow between people of African descent (AD) and European descent (ED) with healthy eyes. Materials and Methods: Retrobulbar and retinal capillary blood flow was assessed in 1 eye of 58 participants (24 AD, 34 ED) with healthy eyes with systemic blood pressure lower than 140/90. Retrobulbar blood flow was measured in the ophthalmic artery (OA), central retinal artery (CRA), nasal posterior ciliary artery (NPCA) and temporal posterior ciliary artery (TPCA). Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) were assessed. Retinal capillary blood flow was assessed using mean retinal flow and avascular space defined as the percent of area measured with no blood flow. Groups were compared using t tests and Pearson correlations were compared using Fisher r-to-z transformation. Results: Compared with people of ED, people of AD had significantly lower EDV in the NPCA (P=0.01), and higher RI in the CRA (P=0.04) and TPCA (P=0.01). No significant differences were observed in mean retinal capillary flow or avascular area. In the CRA, a significant negative correlation was observed between pattern standard deviation and peak systolic velocity (P=0.02) in the AD group and this correlation was significantly different from that observed in the ED group (P=0.01). A significant correlation was also observed between pattern standard deviation and EDV (0.04) in the AD group. Conclusions: This study suggests that retrobulbar blood flow is lower in healthy eyes in persons of AD compared with ED. This may provide a mechanism through which people of AD are at increased risk for ophthalmic diseases such as glaucoma.

AB - Purpose: To investigate differences in ocular blood flow between people of African descent (AD) and European descent (ED) with healthy eyes. Materials and Methods: Retrobulbar and retinal capillary blood flow was assessed in 1 eye of 58 participants (24 AD, 34 ED) with healthy eyes with systemic blood pressure lower than 140/90. Retrobulbar blood flow was measured in the ophthalmic artery (OA), central retinal artery (CRA), nasal posterior ciliary artery (NPCA) and temporal posterior ciliary artery (TPCA). Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) were assessed. Retinal capillary blood flow was assessed using mean retinal flow and avascular space defined as the percent of area measured with no blood flow. Groups were compared using t tests and Pearson correlations were compared using Fisher r-to-z transformation. Results: Compared with people of ED, people of AD had significantly lower EDV in the NPCA (P=0.01), and higher RI in the CRA (P=0.04) and TPCA (P=0.01). No significant differences were observed in mean retinal capillary flow or avascular area. In the CRA, a significant negative correlation was observed between pattern standard deviation and peak systolic velocity (P=0.02) in the AD group and this correlation was significantly different from that observed in the ED group (P=0.01). A significant correlation was also observed between pattern standard deviation and EDV (0.04) in the AD group. Conclusions: This study suggests that retrobulbar blood flow is lower in healthy eyes in persons of AD compared with ED. This may provide a mechanism through which people of AD are at increased risk for ophthalmic diseases such as glaucoma.

KW - Glaucoma

KW - Ocular blood flow

KW - Racial difference

KW - Visual function

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