Differences in ocular blood flow in glaucoma between patients of African and European descent

Brent Siesky, Alon Harris, Lyne Racette, Rania Abassi, Kaarthik Chandrasekhar, Leslie A. Tobe, Jennifer Behzadi, George Eckert, Annahita Amireskandari, Michael Muchnik

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To investigate differences in ocular blood flow in individuals of African descent (AD) and European descent (ED) with open angle glaucoma (OAG). Patients and Methods: A retrospective data analysis was performed on OAG patients of AD and ED who were previously examined for ocular blood flow within the Department of Ophthalmology at Indiana University School of Medicine. Data analysis included blood pressure, heart rate, visual fields, intraocular pressure, ocular perfusion pressure, and color Doppler imaging of retrobulbar vessels. Color Doppler imaging measurements were performed on ophthalmic, central retinal, and nasal and temporal short posterior ciliary arteries, with peak systolic (PSV) and end diastolic velocities (EDV) as well as the Pourcelot vascular resistive index calculated for each vessel. Two-sample t tests of unequal variance were performed with P values <0.05 considered statistically significant. Results: OAG patients of AD had statistically significant lower retrobulbar blood flow values than patients of ED including lower ophthalmic artery PSV (P=0.0001), ophthalmic artery EDV (P=0.0008), central retinal artery PSV (P=0.01), temporal short posterior ciliary artery PSV (P=0.0037), and nasal short posterior ciliary artery PSV (P<0.0001). No significant differences were found in terms of intraocular pressure or visual field parameters. Conclusions: Significantly lower blood flow values were identified in all retrobulbar blood vessels in AD compared with ED OAG patients. These findings suggest that the contribution of ocular blood flow to the disease process may be different in AD compared with ED OAG patients.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalJournal of Glaucoma
Volume24
Issue number2
DOIs
StatePublished - Feb 27 2015

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Open Angle Glaucoma
Glaucoma
Ciliary Arteries
Ophthalmic Artery
Visual Fields
Intraocular Pressure
Nose
Blood Vessels
Color
Retinal Artery
Ophthalmology
Perfusion
Heart Rate
Medicine
Blood Pressure
Pressure

Keywords

  • African descent
  • blood flow
  • glaucoma
  • race

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Differences in ocular blood flow in glaucoma between patients of African and European descent. / Siesky, Brent; Harris, Alon; Racette, Lyne; Abassi, Rania; Chandrasekhar, Kaarthik; Tobe, Leslie A.; Behzadi, Jennifer; Eckert, George; Amireskandari, Annahita; Muchnik, Michael.

In: Journal of Glaucoma, Vol. 24, No. 2, 27.02.2015, p. 117-121.

Research output: Contribution to journalArticle

Siesky, B, Harris, A, Racette, L, Abassi, R, Chandrasekhar, K, Tobe, LA, Behzadi, J, Eckert, G, Amireskandari, A & Muchnik, M 2015, 'Differences in ocular blood flow in glaucoma between patients of African and European descent', Journal of Glaucoma, vol. 24, no. 2, pp. 117-121. https://doi.org/10.1097/IJG.0b013e31829d9bb0
Siesky, Brent ; Harris, Alon ; Racette, Lyne ; Abassi, Rania ; Chandrasekhar, Kaarthik ; Tobe, Leslie A. ; Behzadi, Jennifer ; Eckert, George ; Amireskandari, Annahita ; Muchnik, Michael. / Differences in ocular blood flow in glaucoma between patients of African and European descent. In: Journal of Glaucoma. 2015 ; Vol. 24, No. 2. pp. 117-121.
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AU - Tobe, Leslie A.

AU - Behzadi, Jennifer

AU - Eckert, George

AU - Amireskandari, Annahita

AU - Muchnik, Michael

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AB - Purpose: To investigate differences in ocular blood flow in individuals of African descent (AD) and European descent (ED) with open angle glaucoma (OAG). Patients and Methods: A retrospective data analysis was performed on OAG patients of AD and ED who were previously examined for ocular blood flow within the Department of Ophthalmology at Indiana University School of Medicine. Data analysis included blood pressure, heart rate, visual fields, intraocular pressure, ocular perfusion pressure, and color Doppler imaging of retrobulbar vessels. Color Doppler imaging measurements were performed on ophthalmic, central retinal, and nasal and temporal short posterior ciliary arteries, with peak systolic (PSV) and end diastolic velocities (EDV) as well as the Pourcelot vascular resistive index calculated for each vessel. Two-sample t tests of unequal variance were performed with P values <0.05 considered statistically significant. Results: OAG patients of AD had statistically significant lower retrobulbar blood flow values than patients of ED including lower ophthalmic artery PSV (P=0.0001), ophthalmic artery EDV (P=0.0008), central retinal artery PSV (P=0.01), temporal short posterior ciliary artery PSV (P=0.0037), and nasal short posterior ciliary artery PSV (P<0.0001). No significant differences were found in terms of intraocular pressure or visual field parameters. Conclusions: Significantly lower blood flow values were identified in all retrobulbar blood vessels in AD compared with ED OAG patients. These findings suggest that the contribution of ocular blood flow to the disease process may be different in AD compared with ED OAG patients.

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