Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging

Chun Hui Bao, Peng Liu, Hui Rong Liu, Lu Yi Wu, Xiao Ming Jin, Si Yao Wang, Yin Shi, Jian Ye Zhang, Xiao Qing Zeng, Li Li Ma, Wei Qin, Ji Meng Zhao, Vince D. Calhoun, Jie Tian, Huan Gan Wu

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Abnormal pain processing in the central nervous system may be related to abdominal pain in patients with Crohn's disease (CD). The purpose of this study was to investigate changes in resting-state brain activity in patients with CD in remission and its relationship with the presence of abdominal pain. Twenty-five patients with CD and with abdominal pain, 25 patients with CD and without abdominal pain, and 32 healthy subjects were scanned using a 3.0-T functional magnetic resonance imaging scanner. Regional homogeneity (ReHo) was used to assess resting-state brain activity. Daily pain scores were collected 1 week before functional magnetic resonance imaging. We found that patients with abdominal pain exhibited lower ReHo values in the insula, middle cingulate cortex (MCC), and supplementary motor area and higher ReHo values in the temporal pole. In contrast, patients without abdominal pain exhibited lower ReHo values in the hippocampal/parahippocampal cortex and higher ReHo values in the dorsomedial prefrontal cortex (all P < 0.05, corrected). The ReHo values of the insula and MCC were significantly negatively correlated with daily pain scores for patients with abdominal pain (r -0.53, P 0.008 and r -0.61, P 0.002, respectively). These findings suggest that resting-state brain activities are different between remissive patients with CD with and without abdominal pain and that abnormal activities in insula and MCC are closely related to the severity of abdominal pain.

Original languageEnglish (US)
Pages (from-to)1037-1044
Number of pages8
JournalPain
Volume157
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • Crohn's disease
  • Functional magnetic resonance imaging
  • Neuroplasticity
  • Pain
  • Regional homogeneity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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  • Cite this

    Bao, C. H., Liu, P., Liu, H. R., Wu, L. Y., Jin, X. M., Wang, S. Y., Shi, Y., Zhang, J. Y., Zeng, X. Q., Ma, L. L., Qin, W., Zhao, J. M., Calhoun, V. D., Tian, J., & Wu, H. G. (2016). Differences in regional homogeneity between patients with Crohn's disease with and without abdominal pain revealed by resting-state functional magnetic resonance imaging. Pain, 157(5), 1037-1044. https://doi.org/10.1097/j.pain.0000000000000479