Differences in response to the aversive properties of ethanol in rats selectively bred for oral ethanol preference

J. C. Froehlich, J. Harts, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

A conditioned taste aversion (CTA) paradigm was used to determine whether aversion to the pharmacological effects of ethanol, apart from orosensory cues, can contribute to genetic differences in voluntary ethanol consumption. Four doses of ethanol, administered IP, were paired with the consumption of a 0.1% saccharin solution in rats from the alcohol-preferring (P) and alcohol-nonpreferring (NP) lines. Repeated pairings of saccharin and ethanol in a dose of 1.0 g/kg produced stronger and more prolonged aversion to saccharin in NP rats, compared with P rats, at comparable blood ethanol levels. A low dose of ethanol (0.25 g/kg) produced transient conditioned facilitation of saccharin consumption in P rats, but not in NP rats, at comparable blood ethanol levels. The results suggest that rats of the NP line find the postingestional effects of high-dose ethanol more aversive, and low-dose ethanol less reinforcing, than do rats of the P line. Genetic differences in voluntary ethanol consumption may be due, in part, to differences in aversion to the postingestional effects of ethanol.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume31
Issue number1
DOIs
StatePublished - Sep 1988

Keywords

  • Aversive/rewarding properties of ethanol
  • Conditioned taste aversion
  • Genetics

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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