DIFFERENCES IN SERUM BONE GLA PROTEIN WITH AGE AND SEX

Sol Epstein, Ron Mcclintock, Graeme Bryce, James Poser, Conrad C. Johnston, Siu Hui

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Serum bone Gla protein (BGP) was measured by radioimmunoassay in 166 healthy men and women aged 30-90 years. Serum BGP levels increased with age in both sexes and were higher in women than in men at all ages. The most striking rise occurred in women after age 40-49. BGP was significantly correlated positively with serum alkaline phosphatase and negatively with midshaft and distal bone mass in both sexes. In women only, BGP levels were significantly positively related to levels of immunoreactive parathyroid hormone (iPTH). When age was included in the multiple regression analysis BGP was still correlated with alkaline phosphatase in both sexes and iPTH in women only. Serum BGP levels were significantly higher in 13 osteoporotic patients than in age-matched controls. It is postulated that with increasing age 1,25-dihydroxyvitamin D levels fall, causing a rise in iPTH and thus in bone turnover, which is reflected by a rise in BGP levels.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalThe Lancet
Volume323
Issue number8372
DOIs
StatePublished - Feb 11 1984

ASJC Scopus subject areas

  • Medicine(all)

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    Epstein, S., Mcclintock, R., Bryce, G., Poser, J., Johnston, C. C., & Hui, S. (1984). DIFFERENCES IN SERUM BONE GLA PROTEIN WITH AGE AND SEX. The Lancet, 323(8372), 307-310. https://doi.org/10.1016/S0140-6736(84)90360-X