Differences in Stimulated Androgen Levels in Black and White Obese Adolescent Females

Tamara Hannon, Silva A. Arslanian

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Study Objective: Little is known about racial differences in androgen levels among obese children. The objective of this pilot study was to compare basal and stimulated androgen levels in a cross-sectional sample of obese black and white pubertal females. Study Design, Setting, and Participants: This was cross-sectional study of obese (body mass index ≥ 95th percentile) but otherwise healthy female adolescents (10 black and 12 white; age range 8.8-13.9 y) who underwent adrenocorticotropic hormone stimulation testing at an academic medical center as part of a protocol for the study of obesity-related conditions. Main Outcome Measures: Basal and stimulated androgen levels. Results: White and black participants were similar with regard to pubertal stage, body mass index, percentage body fat, and fasting glucose and insulin levels. Black girls had lower stimulated levels of 17-hydroxyprogesterone, and the differences between basal and stimulated levels of 17-hydroxyprogesterone and androstenedione were lower in black girls. Body mass index was negatively correlated with stimulated cortisol in blacks only (r = -0.69, P = .03). Conclusion: There appear to be race-related differences in stimulated androgen levels in obese adolescent females. These differences deserve further study, as measurements of androgen levels are commonly used in clinical practice and research.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalJournal of Pediatric and Adolescent Gynecology
Volume25
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Androgens
17-alpha-Hydroxyprogesterone
Body Mass Index
Androstenedione
Adrenocorticotropic Hormone
Hydrocortisone
Adipose Tissue
Fasting
Obesity
Cross-Sectional Studies
Outcome Assessment (Health Care)
hydroquinone
Insulin
Glucose
Research

Keywords

  • 17-Hydroxypregnenolone
  • 17-Hydroxyprogesterone
  • ACTH stimulation test
  • Androstenedione
  • Cortisol
  • Dehydroepiandrosterone
  • Obesity
  • Overweight
  • Race
  • Testosterone

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Differences in Stimulated Androgen Levels in Black and White Obese Adolescent Females. / Hannon, Tamara; Arslanian, Silva A.

In: Journal of Pediatric and Adolescent Gynecology, Vol. 25, No. 1, 02.2012, p. 82-85.

Research output: Contribution to journalArticle

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