Different effects of subchronic doses of 17-β estradiol in two ethologically based models of anxiety utilizing female rats

Wendy A. Koss, Donald R. Gehlert, Anantha Shekhar

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Estrogen may have differing effects on 'anxiety' responses under different conditions. The current study tested the effects of estrogen on anxiety-like behavior when administered for 6-7 days in ovariectomized (OVX) female rats. Two animal paradigms were utilized; the elevated plus maze (EPM), measuring changes in innate fear of exploration of open spaces; and the social interaction test (SIT), measuring the exploration of a novel, same gender partner. In the EPM, estradiol-treated OVX females both entered and spent more time in the open arms than control OVX females, indicating an anxiolytic-like action of estradiol. In contrast, estradiol treated OVX females interacted less with the partner animal in the SIT compared with controls suggesting anxiogenic-like effects. The possible anxiogenic effect of estradiol in the SIT is supported by two findings: (1) the effect is reversed by the anxiolytic drug alprazolam and (2) estrogen did not affect locomotion and therefore, the reduced social interaction is not due to reduced activity. Acute administration of progesterone (5 mg/kg), which has anxiolytic properties, did not reverse estradiol-induced social interaction deficits, suggesting that lack of progesterone did not account for estradiol's anxiogenic effects. These results, while seemingly contradictory when interpreted within a unified concept of anxiety, may well reflect the ethological roles of reproductive hormones and their effects on different types of exploratory anxiety.

Original languageEnglish (US)
Pages (from-to)158-164
Number of pages7
JournalHormones and Behavior
Volume46
Issue number2
DOIs
StatePublished - Aug 1 2004

Fingerprint

Interpersonal Relations
Estradiol
Anxiety
Anti-Anxiety Agents
Estrogens
Progesterone
Alprazolam
Space Flight
Locomotion
Fear
Hormones
Pharmaceutical Preparations

Keywords

  • Affective disorders
  • Animal models
  • Anxiety
  • Behavior
  • Drug interaction
  • Elevated plus maze
  • Estrogen
  • Female
  • Progesterone
  • Rat
  • Social interaction

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Different effects of subchronic doses of 17-β estradiol in two ethologically based models of anxiety utilizing female rats. / Koss, Wendy A.; Gehlert, Donald R.; Shekhar, Anantha.

In: Hormones and Behavior, Vol. 46, No. 2, 01.08.2004, p. 158-164.

Research output: Contribution to journalArticle

@article{516ac06f860d42d4a98b958edc0e5d1d,
title = "Different effects of subchronic doses of 17-β estradiol in two ethologically based models of anxiety utilizing female rats",
abstract = "Estrogen may have differing effects on 'anxiety' responses under different conditions. The current study tested the effects of estrogen on anxiety-like behavior when administered for 6-7 days in ovariectomized (OVX) female rats. Two animal paradigms were utilized; the elevated plus maze (EPM), measuring changes in innate fear of exploration of open spaces; and the social interaction test (SIT), measuring the exploration of a novel, same gender partner. In the EPM, estradiol-treated OVX females both entered and spent more time in the open arms than control OVX females, indicating an anxiolytic-like action of estradiol. In contrast, estradiol treated OVX females interacted less with the partner animal in the SIT compared with controls suggesting anxiogenic-like effects. The possible anxiogenic effect of estradiol in the SIT is supported by two findings: (1) the effect is reversed by the anxiolytic drug alprazolam and (2) estrogen did not affect locomotion and therefore, the reduced social interaction is not due to reduced activity. Acute administration of progesterone (5 mg/kg), which has anxiolytic properties, did not reverse estradiol-induced social interaction deficits, suggesting that lack of progesterone did not account for estradiol's anxiogenic effects. These results, while seemingly contradictory when interpreted within a unified concept of anxiety, may well reflect the ethological roles of reproductive hormones and their effects on different types of exploratory anxiety.",
keywords = "Affective disorders, Animal models, Anxiety, Behavior, Drug interaction, Elevated plus maze, Estrogen, Female, Progesterone, Rat, Social interaction",
author = "Koss, {Wendy A.} and Gehlert, {Donald R.} and Anantha Shekhar",
year = "2004",
month = "8",
day = "1",
doi = "10.1016/j.yhbeh.2004.02.011",
language = "English (US)",
volume = "46",
pages = "158--164",
journal = "Hormones and Behavior",
issn = "0018-506X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Different effects of subchronic doses of 17-β estradiol in two ethologically based models of anxiety utilizing female rats

AU - Koss, Wendy A.

AU - Gehlert, Donald R.

AU - Shekhar, Anantha

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Estrogen may have differing effects on 'anxiety' responses under different conditions. The current study tested the effects of estrogen on anxiety-like behavior when administered for 6-7 days in ovariectomized (OVX) female rats. Two animal paradigms were utilized; the elevated plus maze (EPM), measuring changes in innate fear of exploration of open spaces; and the social interaction test (SIT), measuring the exploration of a novel, same gender partner. In the EPM, estradiol-treated OVX females both entered and spent more time in the open arms than control OVX females, indicating an anxiolytic-like action of estradiol. In contrast, estradiol treated OVX females interacted less with the partner animal in the SIT compared with controls suggesting anxiogenic-like effects. The possible anxiogenic effect of estradiol in the SIT is supported by two findings: (1) the effect is reversed by the anxiolytic drug alprazolam and (2) estrogen did not affect locomotion and therefore, the reduced social interaction is not due to reduced activity. Acute administration of progesterone (5 mg/kg), which has anxiolytic properties, did not reverse estradiol-induced social interaction deficits, suggesting that lack of progesterone did not account for estradiol's anxiogenic effects. These results, while seemingly contradictory when interpreted within a unified concept of anxiety, may well reflect the ethological roles of reproductive hormones and their effects on different types of exploratory anxiety.

AB - Estrogen may have differing effects on 'anxiety' responses under different conditions. The current study tested the effects of estrogen on anxiety-like behavior when administered for 6-7 days in ovariectomized (OVX) female rats. Two animal paradigms were utilized; the elevated plus maze (EPM), measuring changes in innate fear of exploration of open spaces; and the social interaction test (SIT), measuring the exploration of a novel, same gender partner. In the EPM, estradiol-treated OVX females both entered and spent more time in the open arms than control OVX females, indicating an anxiolytic-like action of estradiol. In contrast, estradiol treated OVX females interacted less with the partner animal in the SIT compared with controls suggesting anxiogenic-like effects. The possible anxiogenic effect of estradiol in the SIT is supported by two findings: (1) the effect is reversed by the anxiolytic drug alprazolam and (2) estrogen did not affect locomotion and therefore, the reduced social interaction is not due to reduced activity. Acute administration of progesterone (5 mg/kg), which has anxiolytic properties, did not reverse estradiol-induced social interaction deficits, suggesting that lack of progesterone did not account for estradiol's anxiogenic effects. These results, while seemingly contradictory when interpreted within a unified concept of anxiety, may well reflect the ethological roles of reproductive hormones and their effects on different types of exploratory anxiety.

KW - Affective disorders

KW - Animal models

KW - Anxiety

KW - Behavior

KW - Drug interaction

KW - Elevated plus maze

KW - Estrogen

KW - Female

KW - Progesterone

KW - Rat

KW - Social interaction

UR - http://www.scopus.com/inward/record.url?scp=3142540609&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142540609&partnerID=8YFLogxK

U2 - 10.1016/j.yhbeh.2004.02.011

DO - 10.1016/j.yhbeh.2004.02.011

M3 - Article

C2 - 15256305

AN - SCOPUS:3142540609

VL - 46

SP - 158

EP - 164

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

IS - 2

ER -