Different prognostic roles of tumor suppressor gene BAP1 in cancer

A systematic review with meta-analysis

Claudio Luchini, Nicola Veronese, Shinichi Yachida, Liang Cheng, Alessia Nottegar, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Mattia Barbareschi, Matteo Fassan, Laura D. Wood, Aldo Scarpa

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Biallelic inactivation of the tumor suppressor gene BRCA1-associated protein 1 (BAP1) has been demonstrated in several cancers, but its prognostic role has not been completely explained. We aimed to investigate the risk associated with loss of BAP1 (BAP1-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS were searched from database inception until 09/15/2015 without language restrictions. Prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of BAP1 (BAP1+) vs. BAP1- were included. Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to BAP1- adjusted for potential confounders. From 261 hits, 12 studies (including 13 cohorts) with 3,447 participants (BAP1-: n = 697; BAP1+: n = 2,750), with a median follow-up over 60 months, were meta-analyzed. Compared to BAP1+, BAP1- significantly increased all-cause mortality, cancer-specific mortality and risk of recurrence in all the tumor types analyzed, except for mesothelioma, in which the presence of BAP1 mutations correlates with a better prognosis. Furthermore, we demonstrated that BAP1 mutated colorectal and renal carcinomas are associated with high-tumor grading (P < 0.0001), and that BAP1 mutated is more common in women than in men (P < 0.0001). In conclusion, on the basis of our meta-analysis, we have demonstrated a peculiar role of BAP1 in influencing the prognosis in cancer. Thus, BAP1 could be considered as an important potential target for personalized medicine.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
JournalGenes Chromosomes and Cancer
Volume55
Issue number10
DOIs
StatePublished - Oct 1 2016

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BRCA1 Protein
Tumor Suppressor Genes
Meta-Analysis
Neoplasms
Mortality
Recurrence
Precision Medicine
Neoplasm Grading

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics
  • Cancer Research

Cite this

Different prognostic roles of tumor suppressor gene BAP1 in cancer : A systematic review with meta-analysis. / Luchini, Claudio; Veronese, Nicola; Yachida, Shinichi; Cheng, Liang; Nottegar, Alessia; Stubbs, Brendon; Solmi, Marco; Capelli, Paola; Pea, Antonio; Barbareschi, Mattia; Fassan, Matteo; Wood, Laura D.; Scarpa, Aldo.

In: Genes Chromosomes and Cancer, Vol. 55, No. 10, 01.10.2016, p. 741-749.

Research output: Contribution to journalReview article

Luchini, C, Veronese, N, Yachida, S, Cheng, L, Nottegar, A, Stubbs, B, Solmi, M, Capelli, P, Pea, A, Barbareschi, M, Fassan, M, Wood, LD & Scarpa, A 2016, 'Different prognostic roles of tumor suppressor gene BAP1 in cancer: A systematic review with meta-analysis', Genes Chromosomes and Cancer, vol. 55, no. 10, pp. 741-749. https://doi.org/10.1002/gcc.22381
Luchini, Claudio ; Veronese, Nicola ; Yachida, Shinichi ; Cheng, Liang ; Nottegar, Alessia ; Stubbs, Brendon ; Solmi, Marco ; Capelli, Paola ; Pea, Antonio ; Barbareschi, Mattia ; Fassan, Matteo ; Wood, Laura D. ; Scarpa, Aldo. / Different prognostic roles of tumor suppressor gene BAP1 in cancer : A systematic review with meta-analysis. In: Genes Chromosomes and Cancer. 2016 ; Vol. 55, No. 10. pp. 741-749.
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AU - Luchini, Claudio

AU - Veronese, Nicola

AU - Yachida, Shinichi

AU - Cheng, Liang

AU - Nottegar, Alessia

AU - Stubbs, Brendon

AU - Solmi, Marco

AU - Capelli, Paola

AU - Pea, Antonio

AU - Barbareschi, Mattia

AU - Fassan, Matteo

AU - Wood, Laura D.

AU - Scarpa, Aldo

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